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E7152

Sigma-Aldrich

Elastin from human lung

Prepared by non-degradative extraction

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About This Item

CAS Number:
9007-58-3
EC Number:
232-701-4
MDL number:
MFCD00163547
UNSPSC Code:
12352202

biological source

human lung

form

solid

impurities

<1% carbon debris

UniProt accession no.

P15502

storage temp.

2-8°C

InChI

1S/C27H48N6O6/c1-9-17(6)23(32-24(36)19(13-15(2)3)30-18(7)34)26(38)29-14-21(35)31-22(16(4)5)27(39)33-12-10-11-20(33)25(37)28-8/h15-17,19-20,22-23H,9-14H2,1-8H3,(H,28,37)(H,29,38)(H,30,34)(H,31,35)(H,32,36)/t17-,19-,20-,22-,23-/m0/s1

InChI key

DPUYCSDGMSDKKV-MKBYFEBXSA-N

Gene Information

human ... ELN(2006)

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Application

Elastin is a structural protein which has been used in studies of Chronic obstructive pulmonary disease (COPD). It may be used to investigate why there is a lack of repair for these proteins in patients with COPD.

Preparation Note

Prepared by non-degradative extraction from adult lung as described in Starcher, et al.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
SLBH1682V
SLBH0372V
SLBF7614V
SLBF5924V
021M2223V

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Donald A Peyrot et al.
Biomedical optics express, 3(5), 840-853 (2012-05-09)
Several major lung pathologies are characterized by early modifications of the extracellular matrix (ECM) fibrillar collagen and elastin network. We report here the development of a nonlinear fiber-optic spectrometer, compatible with an endoscopic use, primarily intended for the recording of
Purification and comparison of elastins from different animal species.
B C Starcher et al.
Analytical biochemistry, 74(2), 441-447 (1976-08-01)
Mervyn J Merrilees et al.
Respiratory research, 9, 41-41 (2008-05-20)
COPD is characterised by loss of alveolar elastic fibers and by lack of effective repair. Elastic fibers are assembled at cell surfaces by elastin binding protein (EBP), a molecular chaperone whose function can be reversibility inhibited by chondroitin sulphate of
Jessica F Almine et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(9), 3455-3465 (2013-05-15)
Following penetrating injury of the skin, a highly orchestrated and overlapping sequence of events helps to facilitate wound resolution. Inflammation is a hallmark that is initiated early, but the reciprocal relationship between cells and matrix molecules that triggers and maintains
Andrea Grin et al.
Human pathology, 44(12), 2696-2705 (2013-10-01)
Peritoneal involvement in colorectal cancer (CRC) is an adverse prognostic feature, which may prompt consideration of adjuvant chemotherapy in stage II disease. Controversies and challenges surrounding its assessment have led to consideration of peritoneal elastic lamina invasion (ELI) as an
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