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About This Item
Empirical Formula (Hill Notation):
C184H282N50O61S
CAS Number:
Molecular Weight:
4202.57
MDL number:
UNSPSC Code:
51111800
Recommended Products
Amino Acid Sequence
His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
General description
Exendin-3 is a pancreatic secretagogue, which is a member of the glucagon family. It is found in the venom of Heloderma horridurn, which is a Gila monster lizard. It has a molecular mass of 4200Da and is composed of 39 amino acids. 12 amino-acids region in its N-terminal is highly homologous to secretin. Its C-terminal contains an amide group.[1][2]
Application
Exendin-3 has been used to assess its effect in glucagon receptor knockout mice (Gcgr-/-) and wild-type mice, on glucose-stimulated insulin secretion.[3]
Other Notes
Originally isolated from Heloderma horridum (Gila monster lizard) venom.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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J Eng et al.
The Journal of biological chemistry, 265(33), 20259-20262 (1990-11-25)
An amino-terminal histidyl structure (His1) is characteristic of most peptides in the glucagon superfamily. An assay for His1 peptides performed by amino-terminal amino acid sequencing was used to screen venom from the Gila monster lizard, Heloderma horridum. Two His1 peptides
Actions of Helodermatidae venom peptides and mammalian glucagon-like peptides on gastric chief cells.
Rai, A., et al.
The American Journal of Physiology, 265 (1993)
Bioactive peptides from lizard venoms.
J P Raufman
Regulatory peptides, 61(1), 1-18 (1996-01-16)
Heidi Sørensen et al.
Diabetes, 55(12), 3463-3469 (2006-11-30)
In previous studies, glucagon receptor knockout mice (Gcgr(-/-)) display reduced blood glucose and increased glucose tolerance, with hyperglucagonemia and increased levels of glucagon-like peptide (GLP)-1. However, the role of glucagon receptor signaling for the regulation of islet function and insulin
J Eng et al.
The Journal of biological chemistry, 267(11), 7402-7405 (1992-04-15)
The recent identification in Heloderma horridum venom of exendin-3, a new member of the glucagon superfamily that acts as a pancreatic secretagogue, prompted a search for a similar peptide in Heloderma suspectum venom. An amino acid sequencing assay for peptides
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