E6900
Anti-EphA4 antibody produced in goat
affinity isolated antibody, lyophilized powder
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About This Item
biological source
goat
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
mouse
technique(s)
indirect ELISA: 0.5-1.0 μg/mL
western blot: 0.1-0.2 μg/mL
UniProt accession no.
storage temp.
−20°C
Gene Information
mouse ... Epha4(13838)
General description
By immunoblotting and ELISA, the antibody shows ~10% cross-reactivity with recombinant human ephrin-A5 and <5% cross-reactivity with recombinant human EphA1, mouse EphA2, mouse EphA3, rat EphA5, mouse EphA6, mouse EphA7, and mouse EphA8.
Immunogen
recombinant mouse EphA4, extracellular domain, expressed in NSO cells.
Biochem/physiol Actions
EPH receptor A4 is a protein-tyrosine kinase family that belongs to the ephrin receptor subfamily. It binds the ephrin-A and ephrin-B ligands and regulates developmental events, particularly those of the nervous system. EphA4 regulates the axonal growth, astrocyte reactivity and neuroinflammation in experimental autoimmune encephalomyelitis. High expression of EphA4 correlates with tumor progression, invasion and metastasis of gastric cancer and is a suitable prognostic marker.
Physical form
Lyophilized from 0.2 μm filtered solution in phosphate buffered saline.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Bin Shen et al.
Neuropsychiatric disease and treatment, 17, 1667-1678 (2021-06-04)
The aim of our study was to explore the role of long non-coding RNA (lncRNA) growth arrest-specific 5 (GAS5) in ischemic stroke using oxygen-glucose deprivation/reperfusion (OGD/R)-induced bEnd.3 cells as in vitro cell model. Real-time quantitative polymerase chain reaction (RT-qPCR) and
Kohji Miyazaki et al.
BMC clinical pathology, 13(1), 19-19 (2013-06-07)
Erythropoietin-producing hepatocellular (Eph) receptor, consisting of a family of receptor tyrosine kinases, plays critical roles in tumour development and is considered an attractive target for cancer therapy. Tumour samples were obtained from 222 patients with gastric adenocarcinoma who underwent gastrectomy.
Manish Tandon et al.
Expert opinion on therapeutic targets, 15(1), 31-51 (2010-12-15)
High mortality rates with cancers warrant further development of earlier diagnostics and better treatment strategies. Membrane-bound erythropoietin-producing hepatocellular receptor tyrosine kinase class A2 (EphA2) is overexpressed in breast, prostate, urinary bladder, skin, lung, ovary and brain cancers. EphA2 overexpression in
Kathryn M Munro et al.
PloS one, 8(2), e55948-e55948 (2013-02-08)
The EphA4 receptor tyrosine kinase is a major regulator of axonal growth and astrocyte reactivity and is a possible inflammatory mediator. Given that multiple sclerosis (MS) is primarily an inflammatory demyelinating disease and in mouse models of MS, such as
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