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E6033

Sigma-Aldrich

Anti-ECM1 (136-150) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Anti-Extracellular matrix protein 1 precursor

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About This Item

UNSPSC Code:
12352203

biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~61 kDa

species reactivity

human

technique(s)

western blot: 1:500-1:2,000

UniProt accession no.

Q16610

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... ECM1(1893)

Immunogen

synthetic peptide corresponding to amino acids 136-150 of human ECM1

Application

Anti-ECM1 (136-150) antibody produced in rabbit is suitable for western blotting at a dilution of 1:500-1:2,000.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.

Biochem/physiol Actions

Extracellular matrix protein 1 is a protein encoded by the ECM1 gene in humans and is located on chromosome 1q21. It is highly expressed in bone, cartilage, osteogenic, preosteoblastic and chondroblastic cell lines. ECM1 plays an important role by promoting the occurrence, development and metastasis of laryngeal carcinoma. It is also considered as the prime candidate for pycnodysostosis, which is a rare autosomal recessive sclerosing skeletal dysplasia. Overexpression of ECM1 may lead to cholangiocarcinoma (CCA) initiation and progression through promoting migration and invasion of CCA cells. Mutation in ECM1 gene leads to lipoid proteinosis (a rare autosomal recessive disease).

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number
069K2700

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Meizhen Gu et al.
International journal of clinical and experimental pathology, 6(6), 1132-1137 (2013-05-23)
To investigate the expression of extracellular matrix protein 1 (ECM1) in benign laryngeal lesions, precancerous lesions and malignant laryngeal lesions and analyze the clinical significance of ECM1 changes in the pathogenesis and metastasis of laryngeal carcinoma. A total of 46
G P Xiong et al.
Neoplasma, 59(4), 409-415 (2012-04-12)
Although the expression of extracellular matrix protein-1 (ECM1) has been documented in several tumor models, the function of ECM1 has remained unclear. In this study, expression of ECM1 was detected by real time PCR and immunohistochemistry. The role and mechanism
Muhammad Nasir et al.
Diagnostic pathology, 6, 69-69 (2011-07-28)
Lipoid proteinosis is a rare autosomal recessive disease characterized by cutaneous and mucosal lesions and hoarseness appearing in early childhood that is caused by homozygous or compound heterozygous mutations in the ECM1 gene located on chromosome 1q21. The aim of
M R Johnson et al.
Matrix biology : journal of the International Society for Matrix Biology, 16(5), 289-292 (1998-03-21)
Ecm1, the mouse gene encoding extracellular matrix protein 1, is highly expressed in bone and cartilage as well as in osteogenic, preosteoblastic and chondroblastic cell lines. Ecm1 was recently localized to a chromosomal region in mouse syntenic to human chromosome

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