E5892
Anti-EphB1 (ELK Receptor)-EXT antibody produced in sheep
purified immunoglobulin, buffered aqueous solution
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About This Item
biological source
sheep
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 116 kDa
species reactivity
human
technique(s)
immunoprecipitation (IP): 10-20 μg/mL
western blot (chemiluminescent): 1-10 μg/mL
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... EPHB1(2047)
General description
Eph family of tyrosine kinase receptors mediates cell-cell attachment and aggregation by binding to specific ligands, ephrins. The Eph family consists of 14 structurally related receptors that are either membrane linked or are transmembrane with overlapping affinity for ligands. The transmembrane receptors EphA and EphB1 (ELK) subclasses signal via distinct mediators in the cytoplasm. EphB1 binds ephrinB1, recruits Grb2 and Grb10 and mediates cell attachment and cell-cell assembly. Activated EphB1 also reportedly mediates the signaling by c-Jun kinase. The EphB1 receptors are vital in targeting the migration of neurons, angiogenesis and vascular cell assembly during development
Anti-EphB1 (Elk Receptor)-EXT recognizes the external region of human EphB1 protein (116 kDa).
Anti-EphB1 (Elk Receptor)-EXT recognizes the external region of human EphB1 protein (116 kDa).
Immunogen
GST-fusion protein EphB1 (Elk Receptor)-EXT corresponding to amino acids 16-351 of the N-terminal region.
Application
Anti- EphB1 (ELK Receptor)-EXT antibody may be used for immunoblotting at a working concentration of 1-10 μg/ml. Antibody concentration of 10-20 μg/ml is recommended for immunoprecipitation.
Physical form
Solution in phosphate buffered saline with 0.08% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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E Stein et al.
The Journal of biological chemistry, 273(3), 1303-1308 (1998-01-27)
Eph family receptor tyrosine kinases signal axonal guidance, neuronal bundling, and angiogenesis; yet the signaling systems that couple these receptors to targeting and cell-cell assembly responses are incompletely defined. Functional links to regulators of cytoskeletal structure are anticipated based on
D Orioli et al.
Trends in genetics : TIG, 13(9), 354-359 (1997-09-01)
Eph receptors and their ligands have been implicated in axonal pathfinding during the formation of neuronal networks. Whereas other guiding molecules, such as netrins and most semaphorins, are diffusible factors that can guide axons over considerable distances, Eph receptors and
H U Wang et al.
Neuron, 18(3), 383-396 (1997-03-01)
In vertebrate embryos, neural crest cell migration and motor axon outgrowth are restricted to rostral somite halves by repulsive factors located in the caudal somite compartment. We show that two Eph family transmembrane ligands, Lerk2 and HtkL, are expressed in
E Stein et al.
Genes & development, 12(5), 667-678 (1998-04-16)
Eph family receptor tyrosine kinases (including EphA3, EphB4) direct pathfinding of neurons within migratory fields of cells expressing gradients of their membrane-bound ligands. Others (EphB1 and EphA2) direct vascular network assembly, affecting endothelial migration, capillary morphogenesis, and angiogenesis. To explore
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