E5654
Anti-Endonuclease G antibody produced in rabbit
1 mg/mL, affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-EndoG
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About This Item
MDL number:
UNSPSC Code:
12352203
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~35 kDa
species reactivity
rat, mouse, human
concentration
1 mg/mL
technique(s)
ELISA: suitable
immunohistochemistry: suitable
western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ENDOG(2021)
mouse ... Endog(13804)
rat ... Endog(362100)
Immunogen
synthetic peptide corresponding to amino acids 55-70 of human EndoG.
Application
Anti-Endonuclease G antibody produced in rabbit is suitable for western blotting at a dilution of 2μg/mL.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Biochem/physiol Actions
Endonuclease G, mitochondrial is an enzyme encoded by the ENDOG gene in humans. It is mapped to human chromosomes 9q34.1. EndoG a member of DNA/RNA nonspecific ββα-Me-finger nucleases that is involved in apoptosis and normal cellular proliferation. EndoG is localized in the mitochondria of young cells, but relocalizes to the nucleus upon senescence. It plays an important role in the senescence program of human endothelial cells. ENDOG is alo involved in mitochondrial-mediated apoptotic signaling in older human muscle.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Shih-Lu Wu et al.
Journal of biomedical science, 16, 6-6 (2009-03-11)
Endonuclease G (EndoG), a member of DNA/RNA nonspecific betabetaalpha-Me-finger nucleases, is involved in apoptosis and normal cellular proliferation. In this study, we analyzed the critical amino acid residues of EndoG and proposed the catalytic mechanism of EndoG. To identify the
Thomas Diener et al.
Experimental gerontology, 45(7-8), 638-644 (2010-03-10)
Mitotic cells in culture show a limited replicative potential and after extended subculturing undergo a terminal growth arrest termed cellular senescence. When cells reach the senescent phenotype, this is accompanied by a significant change in the cellular phenotype and massive
Gilles Gouspillou et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(4), 1621-1633 (2013-12-29)
Mitochondrial dysfunction is implicated in skeletal muscle atrophy and dysfunction with aging, with strong support for an increased mitochondrial-mediated apoptosis in sedentary rodent models. Whether this applies to aged human muscle is unknown, nor is it clear whether these changes
Núria Bahi et al.
The Journal of biological chemistry, 281(32), 22943-22952 (2006-06-07)
Differentiated cardiomyocytes are resistant to caspase-dependent cell death; however, the mechanisms involved are still uncertain. We previously reported that low Apaf1 expression partially accounts for cardiomyocyte resistance to apoptosis. Here, we extend the knowledge on the molecular basis of cardiac
Takumi Kudo et al.
Cancer research, 72(11), 2901-2911 (2012-05-18)
RASSF3 is the smallest member of the RASSF family of proteins that function as tumor suppressors. Unlike other members of this important family, the mechanisms through which RASSF3 suppresses tumor formation remain unknown. Here, we show that RASSF3 expression induces
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