E4902
Anti-γ-Epithelial Cell Sodium Channel antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-γ-ENaC
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About This Item
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 75 kDa
species reactivity
rat
technique(s)
immunoprecipitation (IP): suitable
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SCNN1G(6340)
rat ... Scnn1g(24768)
Immunogen
synthetic peptide corresponding to amino acids 630-649 of human γ-ENaC.
Application
Anti-γ-Epithelial Cell Sodium Channel antibody produced in rabbit is suitable for the following applications:
- Immunoprecipitation
- Western blotting
- Immunoblotting
Biochem/physiol Actions
The epithelial sodium channel (ENaC) is expressed in sodium-absorbing epithelia and also found in ocular tissues. It may play an important role in aqueous humor secretion and glaucoma. There are four ENaC subunits (αβγδ) and are expressed in the normal human eye. ENaC activation by proteases may be involved in cystic fibrosis, sodium retention and the pathogenesis of arterial hypertension in the context of renal disease. The γ-subunit of the epithelial sodium channel (SCNN1G) are associated with both mendelian and quantitative effects on blood pressure. It helps in blood pressure determination.
Physical form
Solution in phosphate buffered saline containing 1.0 mg/ml bovine serum albumin and 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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Noor A S Ismail et al.
European journal of pharmacology, 732, 32-42 (2014-03-25)
Neural precursor cell expressed, developmentally down-regulated protein 4-2 (Nedd4-2) mediates the internalisation / degradation of epithelial Na(+) channel subunits (α-, β- and γ-ENaC). Serum / glucocorticoid inducible kinase 1 (SGK1) and protein kinase A (PKA) both appear to inhibit this
Bettina Krueger et al.
Investigative ophthalmology & visual science, 53(2), 596-604 (2011-12-15)
The epithelial sodium channel (ENaC) is typically expressed in sodium-absorbing epithelia. Several reports suggest that ENaC is also expressed in ocular tissues and may play a role in aqueous humor secretion and glaucoma. However, the precise localization of ENaC in
Cara J Büsst et al.
Hypertension (Dallas, Tex. : 1979), 58(6), 1073-1078 (2011-10-19)
Variants in the gene encoding the γ-subunit of the epithelial sodium channel (SCNN1G) are associated with both Mendelian and quantitative effects on blood pressure. Here, in 4 cohorts of 1611 white European families composed of a total of 8199 individuals
Zhanjun Jia et al.
American journal of physiology. Renal physiology, 299(1), F155-F166 (2010-03-26)
Aldosterone (Aldo) is a major sodium-retaining hormone that reduces renal sodium excretion and also stimulates sodium appetite. In the face of excess Aldo, the sodium-retaining action of this steroid is overridden by an adaptive regulatory mechanism, a phenomenon termed Aldo
Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S.
Silke Haerteis et al.
Pflugers Archiv : European journal of physiology, 464(4), 353-365 (2012-08-07)
Proteolytic processing of the amiloride-sensitive epithelial sodium channel (ENaC) by serine proteases is known to be important for channel activation. Inappropriate ENaC activation by proteases may contribute to the pathophysiology of cystic fibrosis and could be involved in sodium retention
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