E4767
Monoclonal Anti-S1P2, C-Terminal antibody produced in mouse
clone AS65, purified immunoglobulin, buffered aqueous solution
Synonym(s):
Anti-EDG-5, Anti-Endothelial Cell Differentiation Gene 5, C-Terminal
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About This Item
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biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
AS65, monoclonal
form
buffered aqueous solution
mol wt
antigen ~45 kDa
species reactivity
rat, human
technique(s)
western blot: suitable
isotype
IgG
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... S1PR2(9294)
rat ... S1pr2(29415)
Immunogen
human EDG-5/S1P2 unique C-terminal peptide.
Application
Monoclonal Anti-S1P2, C-Terminal antibody produced in mouse is suitable for western blotting at a working dilution of 1:1000 (1μg/mL) using human T lymphoblasts, ovarian tumor cells, epithelial cells, estrogen receptor positive breast carcinoma cells, human spleen and rat spleen or lung.
Biochem/physiol Actions
Sphingosine-1-phosphate receptor 2 (S1PR2 or S1P2) is a human gene encodes a G protein-coupled receptor. It binds the lipid signaling molecule sphingosine 1-phosphate (S1P) and regulates vascular permeability along with S1P1. Activation of S1P2R in endothelial cells increases vascular permeability. It is a bioactive lysophospholipid capable of inducing a wide spectrum of biological responses. S1P acts as an intercellular mediator by interacting with the endothelial differentiation gene (EDG)/S1P family of G protein-coupled receptors. S1P2 receptor is involved in S1P-induced platelet aggregation and Rho kinase activation. Type 2 diabetes patient responds to S1P.
Target description
EDG-5/S1P2 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-5/S1P2 is sphingosine 1-phosphate, and is expressed in cardiovascular, central nervous system, gonadal, placental and leukocyte-containing tissue.
Preparation Note
Purified from in vitro cell culture supernatants using protein A.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Voahanginirina Randriamboavonjy et al.
Basic research in cardiology, 104(3), 333-340 (2009-01-14)
Sphingosine-1-phosphate (S1P) is known to affect platelet responsiveness but the receptor mediating these effects and the mechanisms involved are poorly understood. This study was undertaken to examine S1P receptor expression in human platelets as well as potential changes associated with
Teresa Sanchez et al.
Arteriosclerosis, thrombosis, and vascular biology, 27(6), 1312-1318 (2007-04-14)
S1P acts via the S1PR family of G protein-coupled receptors to regulate a variety of physiological responses. Whereas S1P1R activates G(i)- and PI-3-kinase-dependent signals to inhibit vascular permeability, the related S1P2R inhibits the PI-3-kinase pathway by coupling to the Rho-dependent
Makoto Osada et al.
Biochemical and biophysical research communications, 299(3), 483-487 (2002-11-26)
Sphingosine 1-phosphate (Sph-1-P), a bioactive lysophospholipid capable of inducing a wide spectrum of biological responses, acts as an intercellular mediator, through interaction with the endothelial differentiation gene (EDG)/S1P family of G protein-coupled receptors. In this study, the effects of JTE-013
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