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E4404

Sigma-Aldrich

Anti-EphA8 antibody produced in goat

affinity isolated antibody, lyophilized powder

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About This Item

MDL number:
MFCD04040318
UNSPSC Code:
51111800
NACRES:
NA.41

biological source

goat

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

mouse

technique(s)

indirect ELISA: 0.5-1.0 μg/mL
western blot: 0.1-0.2 μg/mL

UniProt accession no.

O09127

storage temp.

−20°C

Gene Information

mouse ... Epha8(13842)

General description

The antibody demonstrates ~5% cross-reactivity with recombinant mouse EphA6, EphA7, EphA2, and EphA3 in ELISA and immunoblotting assays. Also, there is approximately 5% cross-reactivity with recombinant human EphA1 and recombinant rat EphA5.

Immunogen

purified recombinant mouse EphA8 extracellular domain.

Biochem/physiol Actions

EPH receptor A8 is a protein-tyrosine kinase family that belongs to the ephrin receptor subfamily. It regulates developmental events, particularly those of the nervous system. EphA8 binds p110γ isoform of PI3-kinase and regulates the integrin-mediated cell adhesion.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

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Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

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C Gu et al.
Molecular and cellular biology, 21(14), 4579-4597 (2001-06-21)
Recent genetic studies suggest that ephrins may function in a kinase-independent Eph receptor pathway. Here we report that expression of EphA8 in either NIH 3T3 or HEK293 cells enhanced cell adhesion to fibronectin via alpha(5)beta(1)- or beta(3) integrins. Interestingly, a
eph, the largest known family of putative growth factor receptors.
N L Tuzi et al.
British journal of cancer, 69(3), 417-421 (1994-03-01)

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