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E3539

Sigma-Aldrich

Proteinase 3 from human leukocytes

≥95% (PAGE)

Synonym(s):

AGP7, Myeloblastin, P29B, PR-3, PR3 Ag

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About This Item

Enzyme Commission number:
3.4.21.76 (BRENDA, IUBMB)
MDL number:
MFCD03458212
UNSPSC Code:
12352204
NACRES:
NA.54

assay

≥95% (PAGE)

form

buffered aqueous solution

UniProt accession no.

P24158

storage temp.

−20°C

Gene Information

human ... PRTN3(5657)

General description

Proteinase 3 is found in high concentration in the primary granules of myeloid leukemia blasts.4

Application

Proteinase 3 has been shown to be important in the pathogenesis of human emphysema.1 It has also been used in a study to investigate the liberation of the antibacterial and cytotoxic peptide LL-37 by cleavage of human cathelicidin hCAP-183.2

Biochem/physiol Actions

Proteinase 3 (PR-3) is a serine protease expressed in the granules of neutrophils and monocytes. Also known as myeloblastin and p29b, it degrades elastin and is associated with myeloid leukemia and Wegener′s granulomatosis.3
Used for the detection of anti-PR3 auto-antibodies in immunoassays.

Physical form

Solution in 50 mM sodium acetate (pH 5) with 600 mM sodium chloride

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
SLCG0033
SLBL5596V
SLBL5594V
SLBQ6747V
SLBL5591V

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