E2907
Anti-EPHA1 (411-425) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
Synonym(s):
Anti-EPH, Anti-EPHT, Anti-EPHT1, Anti-ephrin receptor EphA1 (Homo sapiens)
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About This Item
UNSPSC Code:
12352203
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~108 kDa
species reactivity
human
technique(s)
western blot: 1:500-1:2,000
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... EPHA1(2041)
General description
EPH receptor A1 (ephrin type-A receptor 1) is a protein encoded by the EPHA1 gene in humans. The erythropoietin-producing hepatocellular (Eph) family of receptor tyrosine kinases regulate a multitude of physiological and pathological processes. EphA1 is the first member of Eph superfamily and is involved in carcinogenesis. The protein localizes in the cell membrane.
Immunogen
synthetic peptide corresponding to amino acids 411-425 of human EPHA1.
Application
Anti-EPHA1 (411-425) antibody produced in rabbit is suitable for western blotting at a dilution of 1:500-1:2,000.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.
Biochem/physiol Actions
EphrinA1 is a glycosylphosphatidylinositol (GPI)-linked ligand for the EphA2 receptor, which is overexpressed in glioblastoma (GBM), among other cancers. Its expression level is a potential prognostic marker in gastric cancer. EphA1 was overexpressed in hepatocellular carcinoma (HCC) and that elevated expression can promote proliferation of HCC cells. EphA1 receptor may have roles in carcinogenesis and progression of prostate cancer. It may act as a useful target for prognostic and therapeutic application. EphA1 can to be a differentiation marker for esophageal squamous cells and its increased expression is positively associated with lymph node metastasis and advanced disease stage. EphA1 is also associated with renal cell carcinoma. EphA1 interacts with and blocks integrin-linked kinase (ILK) activity, thereby inhibiting cell spread and migration. EphA1 stimulates migration of CD4+ T cells and CD8+CCR7+ T cells. It also participates in TNF (tumor necrosis factor)-α-mediated adhesion of monocytes to endothelial cells.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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Description
Pricing
Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
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Georg Ende et al.
Journal of molecular and cellular cardiology, 77, 125-135 (2014-12-03)
The ligand ephrin A1 is more often discussed to play a role in the development of the atherosclerotic plaque and in this context especially in the monocyte adhesion to endothelial cells. As tumor necrosis factor-α (TNF-α) is known to induce
Tohru Yamazaki et al.
Journal of cell science, 122(Pt 2), 243-255 (2009-01-02)
The Eph-ephrin receptor-ligand system is implicated in cell behavior and morphology. EphA1 is the founding member of the Eph receptors, but little is known about its function. Here, we show that activation of EphA1 kinase inhibits cell spreading and migration
Hanne S Hjorthaug et al.
European journal of immunology, 37(8), 2326-2336 (2007-07-20)
We have previously demonstrated that binding of ephrin-A1 to Eph receptors on human CD4+ T cells stimulates migration. Here, we show that a distinct population of CD8+ T lymphocytes, expressing the chemokine receptor CCR7, also binds ephrin-A1 and is stimulated
Gang Chen et al.
Oncology reports, 23(2), 563-570 (2010-01-01)
The Eph family of receptor tyrosine kinases has emerged as one of the pivotal regulators of tumor angiogenesis. EphA1, the first identified member of the Eph receptor family, has been found to be overexpressed in several types of human tumors.
Jiandong Wang et al.
Oncology reports, 24(6), 1577-1584 (2010-11-03)
Receptor tyrosine kinases of the Eph subfamily are involved in the development and the carcinogenesis of certain cancers. In this study we investigated expression of EphA1 in gastric carcinomas, and analyzed associations between EphA1 expression and clinicopathological parameters to investigate
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