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E2781

Sigma-Aldrich

Anti-Estrogen-Related Receptor α 1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-ERRα, Anti-ERR1, Anti-NR3B1

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About This Item

MDL number:
MFCD06798438
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~52 kDa (unidentified band is seen at ~37 kDa)

species reactivity

human, rat

technique(s)

western blot: 2 μg/mL using using COS-7 transfected cells

UniProt accession no.

P11474

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... ESRRA(2101)

Immunogen

synthetic peptide M(1)SSQVVGIEPL­YIKAE(16) corresponding to amino acid residues 1-16 from human ERR1 protein.

Biochem/physiol Actions

Estrogen-Related Receptors (ERR) are hormone receptors that bind estrogen response elements that in turn bind specific DNA sequences and regulate transcription. Three ERRs are known, alpha, beta and gamma, with highly conserved ligand and DNA binding sequences. ERRα is selectively expressed in kidney, heart, cerebellum, intestine and skeletal muscle. It is an important modulator of energy balance, food intake, neuropeptide levels and response to stress.

Physical form

Provided as ~100 μg of affinity purified antibody (1 mg/mL) in phosphate buffered saline containing 1 mg/mL bovine serum albumin and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
SLBS9135
038K1449
056K1092

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Angie L Bookout et al.
Cell, 126(4), 789-799 (2006-08-23)
In multicellular organisms, the ability to regulate reproduction, development, and nutrient utilization coincided with the evolution of nuclear receptors (NRs), transcription factors that utilize lipophilic ligands to mediate their function. Studying the expression profile of NRs offers a simple, powerful
Mardi S Byerly et al.
BMC physiology, 13, 10-10 (2013-09-24)
Estrogen-related receptors (ERRs) are orphan nuclear hormone receptors expressed in metabolically active tissues and modulate numerous homeostatic processes. ERRs do not bind the ligand estrogen, but they are able to bind the estrogen response element (ERE) embedded within the ERR

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