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E2127

Sigma-Aldrich

β-Estradiol 3-(β-D-glucuronide) sodium salt

Synonym(s):

1,3,5(10)-Estratriene-3,17β-diol 3-glucuronide, 3,17β-Dihydroxy-1,3,5(10)-estratriene 3-glucuronide

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5 MG
$295.00
10 MG
$523.00
25 MG
$1,100.00

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5 MG
$295.00
10 MG
$523.00
25 MG
$1,100.00

About This Item

Linear Formula:
C24H31O8Na
CAS Number:
14982-12-8
Molecular Weight:
470.49
MDL number:
MFCD00056552
UNSPSC Code:
51111800
PubChem Substance ID:
24894454
NACRES:
NA.77

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sterility

non-sterile

assay

≥98% (HPLC)

form

powder

solubility

water: 10 mg/mL, clear to slightly hazy

shipped in

ambient

storage temp.

−20°C

SMILES string

[Na].CC12CCC3C(CCc4cc(OC5OC(C(O)C(O)C5O)C(O)=O)ccc34)C1CCC2O

InChI

1S/C24H32O8.Na.H/c1-24-9-8-14-13-5-3-12(10-11(13)2-4-15(14)16(24)6-7-17(24)25)31-23-20(28)18(26)19(27)21(32-23)22(29)30;;/h3,5,10,14-21,23,25-28H,2,4,6-9H2,1H3,(H,29,30);;

InChI key

JKYLXXZHJUQLMK-UHFFFAOYSA-N

Application

β-Estradiol 3-(β-D-glucuronide) sodium salt has been used in estrogen administration.[1] It has also been used to determine the amount of two types of glucuronidated estradiols such as estradiol-3- α glucuronide and estradiol-17- β glucuronide.[2]

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BGBC0580
BGBB6955V
038K3786
018F3785

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Sigma-Aldrich

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Direct, complex effects of estrogens on basal forebrain cholinergic neurons
Bora S H, et al.
Experimental Neurology, 194(2), 506-522 (2005)
B T Zhu et al.
Toxicology and applied pharmacology, 136(1), 186-193 (1996-01-01)
Estrogen-induced tumors in kidneys of male Syrian hamsters have been postulated to arise from cells which are damaged by free radicals and other reactive species generated during metabolic redox cycling of catecholestrogens and which at the same time are exposed
Mohamed-Eslam F Mohamed et al.
Xenobiotica; the fate of foreign compounds in biological systems, 40(10), 663-669 (2010-07-30)
Commonly used herbal supplements were screened for their potential to inhibit UGT1A1 activity using human liver microsomes. Extracts screened included ginseng, echinacea, black cohosh, milk thistle, garlic, valerian, saw palmetto, and green tea epigallocatechin gallate (EGCG). Estradiol-3-O-glucuronide (E-3-G) formation was
Letizia Antonilli et al.
Biochemical pharmacology, 76(5), 672-679 (2008-07-22)
We have previously found that repeated exposure to heroin reduces liver synthesis of morphine-3-glucuronide (M3G) and increases the production of morphine-6-glucuronide (M6G), which normally is not formed in the rat. By contrast repeated exposure to naltrexone does not activate M6G
K S Kan et al.
The Biochemical journal, 261(1), 297-300 (1989-07-01)
By using rat liver perfusion under one-pass conditions with a single pulse of horseradish peroxidase (HRP), the biliary output of HRP was used as an indicator of paracellular permeability change caused by the cholestatic compound oestradiol 17 beta-glucuronide (E17G). Since
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