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E2033

Sigma-Aldrich

14-3-3 Epsilon histidine-tagged human

recombinant, expressed in E. coli, C-terminal, ≥90% (SDS-PAGE), buffered aqueous solution

Synonym(s):

14-3-3ε, FLJ45465, KCIP-1, MDCR, MDS, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide, YWHAE

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About This Item

UNSPSC Code:
12352200

recombinant

expressed in E. coli

assay

≥90% (SDS-PAGE)

form

buffered aqueous solution

UniProt accession no.

P62258

shipped in

dry ice

Storage temp.

−20°C

Gene Information

human ... YWHAE(7531)

General description

14-3-3ε is a protein encoded by the YWHAE (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein ε), which is a DISC1 (Disrupted-in-Schizophrenia 1)-interacting protein. It belongs to a family of highly conserved proteins called 14-3-3, which has seven isoforms namely, σ, β, γ, ε, τ, θ, and η. They also contain two isotypes, α and δ, which are phosphorylated. 14-3-3ε is expressed in human brain, and is the oldest isoform of this family.

Biochem/physiol Actions

14-3-3 proteins are involved in a multitude of biological processes and exhibit a regulatory role in processes such as apoptotic cell death, mitogenic signal transduction, and cell cycle control.
14-3-3 proteins are involved in a multitude of biological processes and exhibit a regulatory role in processes such as apoptotic cell death, mitogenic signal transduction, and cell cycle control. 14-3-3ε interacts with various proteins (cdc25 phosphatases, Raf1, and IRS1) in diverse signal trasduction pathways suggesting a role to 14-3-3ε in biological phenomenons such as cell division and regulation of insulin sensitivity. There is a growing emergence of correlative data linking 14-3-3 proteins to various human diseases such as neurodegenerative conditions, cancer, and heart diseases.

Physical form

Supplied as a 0.2 μm filtered solution in 50 mM potassium phosphate buffer and 300 mM sodium chloride.

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Product No.
Description
Pricing

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Diana Morales et al.
Journal of neurovirology, 19(5), 471-478 (2013-08-29)
YWHAE (14-3-3ε) protein levels are considered to be a reliable biomarker for neurodegeneration. The YWHAE protein interacts both directly and indirectly with human immunodeficiency virus (HIV) accessory proteins, leading to cell death. The purpose of this study was to examine
Mikio Kido et al.
PloS one, 9(8), e103571-e103571 (2014-08-12)
YWHAE is a possible susceptibility gene for schizophrenia that encodes 14-3-3epsilon, a Disrupted-in-Schizophrenia 1 (DISC1)-interacting molecule, but the effect of variation in its genotype on brain morphology remains largely unknown. In this voxel-based morphometric magnetic resonance imaging study, we conducted
Anne Kistner et al.
Rheumatology (Oxford, England), 56(5), 829-834 (2017-01-09)
Autoantibodies are useful biomarkers for diagnosing and monitoring treatment in some autoimmune diseases. Antibodies against isoforms of 14-3-3 protein have been proposed as biomarkers for the presence of aortic aneurysm in large-vessel vasculitis (LVV). Here, we aimed to evaluate the

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