E0156
Anti-Estrogen-Related Receptor β antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-ERRβ, Anti-NR3B2
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About This Item
MDL number:
UNSPSC Code:
12352203
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1 μg/mL using human liver, hepatocytes
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... ESRRB(2103)
mouse ... Esrrb(26380)
rat ... Esrrb(299210)
Immunogen
synthetic peptide corresponding to the internal domain of human estrogen-related receptor β, conjugated to KLH. The immunizing peptide has 93% homology with the rat and mouse gene.
Application
Anti-Estrogen-Related Receptor β antibody produced in rabbit was used for immunocytochemistry of neurons from mouse model of glaucoma at a working dilution of 1:500. It was also used for immunohistochemistry of mouse brain sections.
Biochem/physiol Actions
Estrogen-Related Receptors (ERR) are hormone receptors that bind estrogen response elements that in turn bind specific DNA sequences and regulate transcription. Three ERRs are known, alpha, beta and gamma, with highly conserved ligand and DNA binding sequences. ERRβ is selectively expressed in brain and is an important modulator of energy balance, food intake, neuropeptide levels and response to stress.
Physical form
Solution in phosphate buffered saline, containing 0.1% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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S D Crish et al.
Neuroscience, 229, 55-70 (2012-11-20)
Failure of anterograde transport to distal targets in the brain is a common feature of neurodegenerative diseases. We have demonstrated in rodent models of glaucoma, the most common optic neuropathy, early loss of anterograde transport along the retinal ganglion cell
Francisco M Nadal-Nicolás et al.
Zoological research, 44(1), 226-248 (2023-01-04)
Univocal identification of retinal ganglion cells (RGCs) is an essential prerequisite for studying their degeneration and neuroprotection. Before the advent of phenotypic markers, RGCs were normally identified using retrograde tracing of retinorecipient areas. This is an invasive technique, and its
Silmara de Lima et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(23), 9149-9154 (2012-05-23)
The mature optic nerve cannot regenerate when injured, leaving victims of traumatic nerve damage or diseases such as glaucoma with irreversible visual losses. Recent studies have identified ways to stimulate retinal ganglion cells to regenerate axons part-way through the optic
María Angeles Real et al.
Neuroscience letters, 438(1), 48-53 (2008-05-13)
Recently, a new nuclear receptor subfamily has been identified and referred to as estrogen-related receptors. This new group shares sequence similarity, target genes, co-regulatory proteins, and action sites with the estrogen receptors; however, natural estrogens are not estrogen-related receptors ligands.
Mardi S Byerly et al.
BMC physiology, 13, 10-10 (2013-09-24)
Estrogen-related receptors (ERRs) are orphan nuclear hormone receptors expressed in metabolically active tissues and modulate numerous homeostatic processes. ERRs do not bind the ligand estrogen, but they are able to bind the estrogen response element (ERE) embedded within the ERR
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