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D9571

Sigma-Aldrich

Dolasetron mesylate hydrate

≥98% (HPLC), powder

Synonym(s):

Anzemet hydrate, Dolasetron methanesulfonate hydrate

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10 MG
$95.30
50 MG
$294.00

About This Item

Empirical Formula (Hill Notation):
C19H20N2O3 · CH4O3S · xH2O
CAS Number:
115956-13-3
Molecular Weight:
420.48 (anhydrous basis)
MDL number:
MFCD30478915
UNSPSC Code:
12352200
PubChem Substance ID:
329798907
NACRES:
NA.77

$95.30

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Request a Bulk Order

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

H2O: >30 mg/mL

originator

Sanofi Aventis

storage temp.

2-8°C

SMILES string

O.CS(O)(=O)=O.O=C1CN2[C@@H]3C[C@H](C[C@H]2CC1C3)OC(=O)c4c[nH]c5ccccc45

InChI

1S/C19H20N2O3.CH4O3S.H2O/c22-18-10-21-12-5-11(18)6-13(21)8-14(7-12)24-19(23)16-9-20-17-4-2-1-3-15(16)17;1-5(2,3)4;/h1-4,9,11-14,20H,5-8,10H2;1H3,(H,2,3,4);1H2/t11?,12-,13+,14+;;

InChI key

QTFFGPOXNNGTGZ-BHSFMSKKSA-N

Biochem/physiol Actions

Dolasetron mesylate hydrate is a highly selective serotonin 5-HT3 receptor antagonist.
Dolasetron mesylate hydrate is a highly specific and selective serotonin 5-HT3 receptor antagonist, not shown to have activity at other known serotonin receptors and with low affinity for dopamine receptors.

Features and Benefits

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000205061
0000205060
031M4708V
114M4744V

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Lauren Trepanier
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Mehdi Hamadani et al.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 13(2), 69-75 (2007-09-18)
The last decade has witnessed the great impact of 5-hydroxytryptamine-3 receptor (5-HT(3))antagonists in revolutionizing the management of platinum-based chemotherapy-induced acute nausea and vomiting (CINV). However, despite the availability of a variety of 5-HT(3) antagonists, little data is published to support
Edward B Silberstein
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 49(4), 546-549 (2008-03-18)
The goal of this study was to reduce the salivary symptoms of pain and xerostomia caused by 131I therapy for papillary and follicular thyroid carcinoma. In a single-blind controlled prospective study of 60 patients, we investigated whether pilocarpine, 5 mg
[Pharmacokinetic and pharmacodynamic features of palonosetron].
Armando A Genazzani et al.
Tumori, 94(2), suppl 6-suppl13 (2008-06-21)
Christopher M Peters et al.
Brain research, 1352, 83-93 (2010-07-20)
The balance between descending inhibition and facilitation is thought to be disturbed in chronic pain states. Increased facilitation by spinally released serotonin has been suggested by demonstration that mechanically evoked neuronal responses of wide dynamic range neurons are inhibited by
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