The chemicals encyclopedia published by the Royal Society of Chemistry (11th ed., entry #2939) reports a melting point of 217-218°C.
D9302
Diacerein
≥95% (HPLC)
Synonym(s):
1,8-Diacetoxy-3-carboxyanthraquinone
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About This Item
Empirical Formula (Hill Notation):
C19H12O8
CAS Number:
Molecular Weight:
368.29
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
237-310-2
MDL number:
Assay:
≥95% (HPLC)
Form:
powder
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assay
≥95% (HPLC)
form
powder
SMILES string
CC(=O)Oc1cccc2C(=O)c3cc(cc(OC(C)=O)c3C(=O)c12)C(O)=O
InChI
1S/C19H12O8/c1-8(20)26-13-5-3-4-11-15(13)18(23)16-12(17(11)22)6-10(19(24)25)7-14(16)27-9(2)21/h3-7H,1-2H3,(H,24,25)
InChI key
TYNLGDBUJLVSMA-UHFFFAOYSA-N
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This Item | |||
|---|---|---|---|
| form powder | form solid | form liquid | form - |
| assay ≥95% (HPLC) | assay - | assay ≥96.5% (GC), 97% | assay - |
| Quality Level 200 | Quality Level - | Quality Level 100 | Quality Level - |
Biochem/physiol Actions
Diacerin is an inhibitor of Interleukin-1B (IL-1B) production.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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N de Isla et al.
Bio-medical materials and engineering, 20(3), 227-233 (2010-10-12)
The FoxO family of Forkhead transcription factors functions at the interface of tumor suppression, energy metabolism and organismal longevity. FoxO factors are key downstream targets of insulin, growth factor, nutrient and oxidative stress stimuli that coordinate a wide-range of cellular
Kuljinder Singh et al.
International journal of rheumatic diseases, 15(1), 69-77 (2012-02-14)
To evaluate clinical effectiveness of diacerein as an adjuvant to diclofenac sodium in treatment of Indian patients with symptomatic osteoarthritis (OA) knee. This is a prospective, double-blind, placebo-controlled and intention-to-treat study. An initial washout period of 1 week, was followed
Ren-Yeong Huang et al.
Medical hypotheses, 79(2), 165-167 (2012-05-16)
Periodontal diseases are chronic inflammatory diseases characterized by the destruction of the tooth-supporting structures. They are the most prevalent form of bone pathology in humans and act as a modifying factor of the systemic health of patients. Accumulating evidence has
P Härle et al.
Der Internist, 49(12), 1458-1462 (2008-11-18)
There is an increasing incidence in osteoarthritis, particularly following the 5th life-decade. However, also young people may suffer from severe osteoarthritis, which is estimated to be the most common cause of disability in adults resulting in substantial economic burden. To
Amit Kumar Aggarwal et al.
Drug development and industrial pharmacy, 37(10), 1181-1191 (2011-04-01)
Diacerein (DCN) is a new anti-inflammatory analgesic and antipyretic drug developed specially for the treatment of osteoarthritis. DCN is a poorly water-soluble drug with relatively low bioavailability. Therefore, the purpose of this study was to enhance the solubility and dissolution
Global Trade Item Number
| SKU | GTIN |
|---|---|
| D9302-50MG | 04061833590591 |
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What is the melting point of Product D9302, Diacerein?
1 answer-
Helpful?
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What is the biological activity of Product D9302, Diacerein?
1 answer-
Martindale, 30th ed. indicates that "Diacerein is a non-steroidal anti-inflammatory agent that has been used in musculoskeletal and joint disorders." Diacerein acts by inhibiting interleukin-1. The chemicals encyclopedia published by the Royal Society of Chemistry, 11th ed., indicates that Diacerein "demonstrates anti-arthritic activity without inhibiting prostaglandin synthesis".
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What is the mechanism of action of Product D9302, Diacerein?
1 answer-
"Diacerein is a slow acting symptomatic treatment of osteoarthritis which has demonstrated efficacy on functional manifestations of osteoarthritis and on the structural component. Two mechanisms of action have been validated: in vitro inhibition of interleukin-1 (IL-1) synthesis, the main cytokine involved in cartilage destruction, and activity on the synthesis of proteoglycans, and hyaluronic acid, the principal component of cartilage. Other studies presented here have provided further details concerning other mechanisms of action of diacerein", according to Presse Med., 33(9 Pt 2), S10-S12 (2004).
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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Can Product D9302, Diacerein, be dissolved in DMSO?
1 answer-
Yes. Diacerein is soluble in DMSO at 1 mg/mL. The compound is also soluble in acetic acid at a concentration of 25 mg in 8 mL, as stated on the specification sheet.
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