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D6817

Sigma-Aldrich

Anti-D4 Dopamine Receptor antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-DRD4

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About This Item

MDL number:
MFCD00675239
UNSPSC Code:
12352203

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 3 μg/mL using human brain, neurons

UniProt accession no.

P21917

shipped in

dry ice

Storage temp.

−20°C

Gene Information

human ... DRD4(1815)
mouse ... Drd4(13491)
rat ... Drd4(25432)

General description

D4 Dopamine Receptor expression has been reported in various regions of the brain as well as in adrenal gland, artery, eye, heart, kidney, placenta, spinal cord, testis, and vas deferens.

Immunogen

synthetic peptide corresponding to the third cytoplasmic loop of human D4 dopamine receptor. The immunizing peptide has 79% homology with the rat and mouse gene.

Application

Anti-D4 Dopamine Receptor antibody produced in rabbit is suitable for immunohistochemistry with a working concentration of 3μg/mL using human brain, neurons.

Biochem/physiol Actions

This gene encodes the D4 subtype of the dopamine receptor that is responsible for neuronal signaling in the mesolimbic system of the brain. It is a G-protein coupled receptor which inhibits adenylyl cyclase. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking.

Physical form

Solution in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
087K1899
084K1281

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Amina S Woods
Journal of receptor and signal transduction research, 30(5), 331-336 (2010-09-15)
The human D4 dopamine receptor is a synaptic neurotransmitter receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its structure makes it a very unusual and
Albert H C Wong et al.
Progress in neuro-psychopharmacology & biological psychiatry, 27(7), 1091-1099 (2003-12-04)
The dopamine D4 receptor (D4) is a target for most common neuroleptic medications. After its initial discovery, it was found to possess the highest affinity of all dopamine receptor subtypes for the archetypical, atypical, antipsychotic clozapine. Nevertheless, initial clinical trials
H H Van Tol et al.
Nature, 358(6382), 149-152 (1992-07-09)
The dopamine D4 receptor structurally and pharmacologically resembles the dopamine D2 and D3 receptors. Clozapine, an atypical antipsychotic that is relatively free of the adverse effects of drug-induced parkinsonism and tardive dyskinesia, binds to the D4 receptor with an affinity

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