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Key Documents

D4197

Sigma-Aldrich

SigMatrix Serum Diluent

For in-vitro Diagnostic Use

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About This Item

UNSPSC Code:
12352204

biological source

human

recombinant

expressed in rice

form

solution

concentration

18-22 mg/mL Biuret

pH

7.2-7.6

application(s)

hematology
histology

shipped in

wet ice

storage temp.

2-8°C

General description

For more information on other Sigmatrix products visit the Sigmatrix Selection Guide.
SigMatrix is a serum diluent that utilizes recombinant human albumin as the source of the albumin blocking reagent. The use of human albumin expressed in rice can eliminate the source of interfering analytes typically found in human and bovine-derived diluents. Many commercially-available diluents rely on charcoal-stripping which often only results in limited reduction of interfering analytes.

Application

Poster: Use of an Animal-free Synthetic Surrogate Serum Matrix for Preparation of Calibrators and Controls in Immuno- and LC-MS Based Clinical Assays

Suitability

Recommended for use in ELISA and LC-MS-based diagnostic applications.

Physical form

SigMatrix Serum Diluent is an aqueous solution containing 2% recombinant human albumin (expressed in rice) in phosphate buffered saline (pH 7.4) with 0.1% ProClin™ 950.

Legal Information

ProClin is a trademark of LANXESS Corp.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H317

Hazard Classifications

Skin Sens. 1

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
SLCF5928
SLBX6464
SLCC3473
SLBZ1021
SLBZ6084

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Lucia S Capano et al.
Cell stem cell, 29(6), 918-932 (2022-06-07)
Tau is a microtubule-binding protein expressed in neurons, and the equal ratios between 4-repeat (4R) and 3-repeat (3R) isoforms are maintained in normal adult brain function. Dysregulation of 3R:4R ratio causes tauopathy, and human neurons that recapitulate tau isoforms in

Questions

  1. Is there a replacement available for the discontinued product D4197 in a 100ml size?

    1 answer

    1. There are two other SigMatrix Serum Diluent products available, each with a different regulatory status. D4197 has a regulatory status of 600, D5322 has a regulatory status of 200, and D5197 has a regulatory status of 500. A table on the M Clarity page describes the differences between these regulatory quality levels. All three part numbers appear to be recombinant human albumin. For more information, you can visit the M Clarity page here. Additionally, there are separate links for products D5322 and D5197:

      D5322
      D5197

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