DR3 is a member of the TNF superfamily. It is expressed in lymphocyte rich tissues such as blood, thymus and spleen.
Immunogen
synthetic peptide corresponding to amino acids 59-77 of the extracellular domain of human DR3 precursor.
Application
Anti-DR3 antibody produced in rabbit is suitable for immunoblotting at a working concentration of 0.5μg/mL using total cell lysates from Jurkat cells. It was used as a primary antibody in immunoblotting analysis of adenocarcinoma cells to examine 14-3-3 isoforms expressed in normal and cancerous lung tissues.
Biochem/physiol Actions
DR3 is a death domain-containing receptor that is involved in inducing apoptosis or programmed cell death in cells. Binding of ligand to these receptors sends signals that activate members of the caspase family of proteases, which cause the degradation of chromosomal DNA by activating DNase. It also activates NF-κB, a protein complex that controls transcription of DNA.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide
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International journal of cancer, 113(3), 359-363 (2004-09-30)
14-3-3 Proteins play important roles in a wide range of vital regulatory processes, including signal transduction, apoptosis, cell cycle progression and DNA replication. In mammalian cells, 7 14-3-3 isoforms (beta, gamma, epsilon, eta, sigma, theta and zeta) have been identified
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 18(7), 439-450 (1998-08-26)
Apoptotic signals are transduced by five death domain-containing receptors--TNFR1, Fas, DR3, DR4, and DR5--by binding to their ligands. The intracellular portion of all these receptors contains a region, approximately 80 amino acids long, referred to as the "death domain" (DD).
Science (New York, N.Y.), 274(5289), 990-992 (1996-11-08)
Tumor necrosis factor receptor-1 (TNFR-1) and CD95 (also called Fas or APO-1) are cytokine receptors that engage the apoptosis pathway through a region of intracellular homology, designated the "death domain." Another death domain-containing member of the TNFR family, death receptor
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