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D3190

Sigma-Aldrich

Dithiobiuret

97%, solid

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1 G
$199.00

$199.00

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1 G
$199.00

About This Item

CAS Number:
541-53-7
EC Number:
208-784-8
MDL number:
MFCD00037832
UNSPSC Code:
12352200
PubChem Substance ID:
24893733
NACRES:
NA.77

$199.00

Available to ship onMay 01, 2025Details

Request a Bulk Order

Quality Level

200

assay

97%

form

solid

SMILES string

NC(=S)NC(N)=S

InChI

1S/C2H5N3S2/c3-1(6)5-2(4)7/h(H5,3,4,5,6,7)

InChI key

JIRRNZWTWJGJCT-UHFFFAOYSA-N

General description

Paralytic agent.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
071K2009

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W R Porter et al.
Neurotoxicology, 4(4), 57-68 (1983-01-01)
[14C] Dithiobiuret (DTB)-derived radioactivity is eliminated by adult male rats with an approximate plasma half-life of 8-10 hr. About 65-75% of an i.p. dose appears in the urine within 24 hr after treatment and about 2-4% appears in the feces
W D Atchison
The Journal of pharmacology and experimental therapeutics, 249(3), 735-743 (1989-06-01)
Daily treatment of rats with 2,4-dithiobiuret (DTB, 1 mg/kg/day i.p.) produces a flaccid neuromuscular weakness first observed in the hindlimbs after 5 to 6 days of treatment. This condition is characterized by diminished contractile strength following single shock and tetanic
L M Ireland et al.
The Journal of pharmacology and experimental therapeutics, 275(3), 1453-1462 (1995-12-01)
Chronic administration of 2,4-dithiobiuret (DTB), causes delayed-onset neuromuscular weakness in rats. This effect results from inhibition of quantal release of acetylcholine (ACh) from motor nerve terminals. The effects of noncholinergic neurotransmission are unknown. The purpose of the present study was
M H Weiler et al.
Toxicology and applied pharmacology, 84(2), 220-231 (1986-06-30)
Effects of 2,4-dithiobiuret (DTB) treatment in rats on neuromuscular transmission and the disposition of cholinergic substances, acetylcholine (ACh) and choline (Ch), were examined in a combined electrophysiological/biochemical study using an in vitro extensor digitorum longus (EDL) muscle-peroneal nerve preparation. EDL
K D Williams et al.
Neurotoxicology, 3(4), 221-231 (1982-12-01)
Our main objective was to describe the metabolism of dithiobiuret (DTB) in the adult, male rat. Based on the thin-layer chromatographic analysis of urine from animals treated ip with 1 mg/kg of [14C] or [35S] labeled DTB, two pathways for
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