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D2943

Sigma-Aldrich

Monoclonal Anti-PARK7 (DJ-1) antibody produced in mouse

~2 mg/mL, clone E2.1, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-Oncogene DJ1, Anti-Parkinson Disease (Autosomal Recessive, Early Onset) 7

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About This Item

MDL number:
MFCD08705594
UNSPSC Code:
12352203

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

E2.1, monoclonal

form

buffered aqueous solution

species reactivity

human

concentration

~2 mg/mL

technique(s)

immunohistochemistry: suitable
western blot: 0.5-1.0 μg/mL using total cell extract of HEK 293T cells

UniProt accession no.

Q99497

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... PARK7(11315)

Immunogen

full-length recombinant human DJ-1 protein.

Application

Monoclonal Anti-PARK7 (DJ-1) antibody produced in mouse is suitable for immunohistochemistry and western blot at a concentration of 0.5-1.0μg/mL using total cell extract of HEK 293T cells.

Biochem/physiol Actions

PARK7 is a member of novel glyoxalase family. It exerts mitochondrial activity. It has been suggested that PARK7 may act as an antioxidant and/or a molecular chaperone. It may also detoxify aggressive metabolic aldehyde by-products. It helps in stabilizing mitochondria during cellular stress. Alteration in gene function affects neurodegeneration, which leads to the autosomal recessive early-onset parkinsonism.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
016K4752

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Huw R Morris
Annals of medicine, 37(2), 86-96 (2005-07-20)
Twenty years ago Parkinson's disease (PD) was thought of as an environmentally determined neurodegenerative disease. It is now known that there are two autosomal dominant disease genes, alpha-synuclein and dardarin, and three genes responsible for autosomal recessive PD, parkin, DJ-1
Mark R Cookson
Annual review of biochemistry, 74, 29-52 (2005-06-15)
Several genes have been identified for monogenic disorders that variably resemble Parkinson's disease. Dominant mutations in the gene encoding alpha-synuclein enhance the propensity of this protein to aggregate. As a consequence, these patients have a widespread disease with protein inclusion
Yaacov Hod
Journal of cellular biochemistry, 92(6), 1221-1233 (2004-07-20)
DJ-1 is a conserved protein reported to be involved in diverse cellular processes ranging from cellular transformation, control of protein-RNA interaction, oxidative stress response to control of male infertility, among several others. Mutations in the human gene have been shown
Darren J Moore et al.
Annual review of neuroscience, 28, 57-87 (2005-07-19)
Parkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic neurons in the substantia nigra. Although the etiology of PD is incompletely understood, the recent discovery of genes associated with rare monogenic forms
Binbin Han et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 39(6), 1010428317714625-1010428317714625 (2017-06-28)
DJ-1 is a novel oncogene that can transform NIH3T3 cells in cooperation with the activated ras gene. DJ-1 appears to have its greatest effect on tumourigenesis, and it may have a greater impact on early-stage lung cancers. In this study
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