synthetic peptide corresponding to an internal sequence of human β-Defensin 3.
Application
Anti-β-Defensin 3 antibody produced in rabbit is suitable for immunoblotting at a working dilution of 1:500 to 1:1000 and for immunohistochemistry at 1:2 dilution. It was used for a quantitative immunohistochemical study of HBD-3 on skin lesions from patients having Kaposi′s sarcoma in a study. It was used as a primary antibody for western blot analysis of oral mucosa and extraoral skin samples to study the quantitative comparison of the expression of antimicrobial peptides.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below. Immunohistochemistry (1 paper)
Biochem/physiol Actions
hBD-3 m-RNA expression is induced by tumor necrosis factor a and contact with bacteria. Therefore, it might be important in the innate epithelial defense of infections by various microorganisms seen in skin and lung, such as cystic fibrosis.
Target description
β-Defensin 3 encodes defensin, beta 103B, which has broad spectrum antimicrobial activity and may play an important role in innate epithelial defense.
Physical form
solution in phosphate buffered saline, containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
The British journal of oral & maxillofacial surgery, 50(5), 447-453 (2011-08-09)
Antimicrobial peptides (AMP) defend epithelial surfaces against pathological micro-organisms. We know of no comparison of their expression between the oral mucosa and extraoral epithelium, but knowledge of differences in their quantities is of interest, possibly as a starting point for
The Journal of experimental biology, 223(Pt 6) (2020-02-27)
In cohort splitting, diverging sub-cohorts may show substantial differences in their growth and developmental rates. Although in the past, causes and adaptive value of cohort splitting were studied in detail, individual-level consequences of cohort splitting are still rather overlooked. Life
Kaposi's sarcoma (KS) is a rare neoplasm of lymphatic endothelial cells. Human herpes virus 8 (HHV-8) is considered to be a necessary, but not sufficient causal agent of KS and additional cofactors remain unknown. In this study we evaluated the
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