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D0761

Sigma-Aldrich

Diacetoxyscirpenol

from Fusarium sambucinum

Synonym(s):

12,13-Epoxytrichothec-9-ene-3,4,15-triol-4,15-diacetate, 4β,15-Diacetoxy-3α-hydroxy-12,13 epoxy-trichothec-9-ene, Anguidin

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About This Item

Empirical Formula (Hill Notation):
C19H26O7
CAS Number:
2270-40-8
Molecular Weight:
366.41
Beilstein/REAXYS Number:
1354986
EC Number:
218-873-3
MDL number:
MFCD00866334
UNSPSC Code:
12352200
PubChem Substance ID:
24893292

biological source

Fusarium sambucinum

storage temp.

2-8°C

SMILES string

CC(=O)OC[C@]12CCC(C)=C[C@H]1O[C@@H]3[C@H](O)[C@@H](OC(C)=O)[C@@]2(C)[C@@]34CO4

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pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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A Thuvander et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 37(6), 639-648 (1999-09-09)
The trichothecenes are mycotoxins produced by fungi of the genus Fusarium, which are commonly present in foods and feed of cereal origin. Owing to the lack of sufficient toxicological data for most of the trichothecenes, in vitro studies may contribute
Daisuke Masuda et al.
Journal of experimental botany, 58(7), 1617-1626 (2007-04-12)
Non-volatile sesquiterpenoids, a trichothecene family of phytotoxins such as deoxynivalenol (DON) and T-2 toxin, contain numerous molecular species and are synthesized by phytopathogenic Fusarium species. Although trichothecene chemotypes might play a role in the virulence of individual Fusarium strains, the
Do Youn Jun et al.
Toxicology and applied pharmacology, 222(2), 190-201 (2007-06-15)
To understand the mechanism underlying T-cell toxicity of diacetoxyscirpenol (DAS) from Fusarium sambucinum, its apoptogenic as well as growth retardation activity was investigated in human Jurkat T cells. Exposure to DAS (0.01-0.15 microM) caused apoptotic DNA fragmentation along with caspase-8
J Brake et al.
Poultry science, 78(12), 1690-1694 (2000-01-08)
Two experiments were conducted to determine the effects of 4,15-diacetoxyscirpenol (DAS) on fertility and hatchability of broiler breeders. In Experiment 1, naturally mated broiler breeders were studied. A limited daily allocation of feed containing 0 (basal), 1.25, 2.5, or 5.0
L F Kubena et al.
Poultry science, 76(2), 256-264 (1997-02-01)
The individual and combined effects of feeding diets containing 300 mg fumonisin B1 (FB1), and 4 mg diacetoxyscirpenol (DAS) or 3 mg ochratoxin A (OA) were evaluated in two experiments using female turkey poults (Nicholas Large Whites) from day of
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