CS0080
Epidermal Growth Factor Receptor ELISA human
sufficient for 96 tests
Synonym(s):
Epidermal Growth Factor Receptor ELISA, EGFR ELISA
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About This Item
UNSPSC Code:
12352202
usage
sufficient for 96 tests
shipped in
wet ice
storage temp.
2-8°C
Gene Information
human ... EGFR(1956)
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Application
Epidermal Growth Factor Receptor ELISA detects total EGFR in cell lysates.
The assay is designed for the quantitative determination of epidermal growth factor receptor.
Biochem/physiol Actions
EGFR, a member of the family of receptor tyrosine kinases, is a full length, type I transmembrane glycoprotein. In vivo phosphorylation of EGFR specific tyrosine sites, including Tyr1173 or Tyr1068, activates EGFR and downstream molecules.
Features and Benefits
EGFR ELISAs are fast (total time 4 hours), sensitive, and specific assays. The kit contains precoated plates, all incubations proceed at room temperature, and no proprietary equipment is required.
Analysis Note
Specifically measures both phosphorylated and non-phosphorylated forms of EGFR with a sensitivity of <0.08 ng/mL, which is 10 times more sensitive than immunoblotting.
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Fredrik Jerhammar et al.
Oral oncology, 50(9), 832-839 (2014-07-06)
Targeted therapy against the epidermal growth factor receptor (EGFR) only variably represents a therapeutic advance in head and neck squamous cell carcinoma (HNSCC). This study addresses the need of biomarkers of treatment response to the EGFR-targeting antibody cetuximab (Erbitux®). The
Mei-Chi Chang et al.
PloS one, 9(7), e101959-e101959 (2014-07-23)
Chewing of betel quid (BQ) increases the risk of oral cancer and oral submucous fibrosis (OSF), possibly by BQ-induced toxicity and induction of inflammatory response in oral mucosa. Primary gingival keratinocytes (GK cells) were exposed to areca nut (AN) components
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