Human lymphoblastoid, Xeroderma pigmentosum heterozygote, EBV-transformed
Cell Line Description
Established by EBV transformation of mononuclear cells from peripheral blood of a 41 year old male. The patient was shown to be heterozygote for Xeroderma pigmentosum (XP) group A, a rare, autosomal recessive disease with DNA repair deficiencies. A cell line established from a child of this patient with XP is available (LB708, Sigma Catalogue number. 98062337).
Application
Toxicity studies, hprt mutation analysis, DNA repair deficiencies
Maintain cultures between 3-9 x 100,000 cells/ml, dilute every 1-2 days to 3 x 100,000 cells/ml; 5% CO2, 37°C.
Other Notes
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