C9603
Anti-c-Cbl antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
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About This Item
MDL number:
UNSPSC Code:
12352203
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 120 kDa
species reactivity
human
technique(s)
immunoprecipitation (IP): suitable
microarray: suitable
western blot: 1:1,000-1:5,000
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... CBL(867)
General description
The proto-oncogene product c-Cbl (p120cbl) is a 120kD cytoplasmic protein found mainly in hematopoietic cell lines. It is located in the cytoplasm and cytoskeleton and has a crucial role in tyrosine kinase-dependent signaling pathways. It also has a pivotal role in hematopoietic cell kinase (Hck) induced signaling of hematopoietic cells. Anti-c-Cbl antibody can be used in immunoprecipitation for detecting and localizing c-Cbl. Rabbit anti-c-Cbl antibody reacts specifically with c-Cbl (120 kD) from human.
Immunogen
Synthetic peptide corresponding to the C-terminal region of human c-Cbl (amino acids 889-906) conjugated to KLH.
Application
Anti-c-Cbl antibody can be used in western blotting (diluted 1:1,000-1:5,000) to detect c-Cbl. It can also be used in microarray.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Mary E Peterson et al.
Immunity, 29(4), 578-588 (2008-10-07)
Many cellular responses, such as autoimmunity and cytotoxicity, are controlled by receptors with cytoplasmic immunoreceptor tyrosine-based inhibition motifs (ITIMs). Here, we showed that binding of inhibitory natural killer (NK) cell receptors to human leukocyte antigen (HLA) class I on target
v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas.
W Y Langdon et al.
Proceedings of the National Academy of Sciences of the United States of America, 86(4), 1168-1172 (1989-02-01)
Cas NS-1 is an acutely transforming murine retrovirus that induces pre-B and pro-B cell lymphomas. Molecular cloning showed it was generated from the ecotropic Cas-Br-M virus by sequential recombinations with endogenous retroviral sequences and a cellular oncogene. The oncogene sequence
C J Howlett et al.
Biochemical and biophysical research communications, 257(1), 129-138 (1999-03-27)
Hematopoietic cell kinase (Hck) is a member of the Src-family of protein tyrosine kinases. We have found that upon enzymatic activation of Hck by the heavy metal mercuric chloride, there was a rapid increase in the levels of tyrosine phosphorylation
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