C7987

Anti-CIDE-A, C-Terminal antibody produced in rabbit

~0.5 mg/mL, affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-Cell Death-Inducing DFF-like Effector A
• MDL number: MFCD02096096
• UNSPSC Code: 12352203

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~23 kDa
• species reactivity: human
• concentration: ~0.5 mg/mL
• technique(s): western blot: 1:1,000-1:2,000
• UniProt accession no.: O60543
• shipped in: dry ice
• storage temp.: −20°C
• Gene Information: human ... CIDEA(1149)

Description

Immunogen

synthetic peptide corresponding to amino acids 200-217 of human CIDE-A.

Application

Anti-CIDE-A, C-Terminal antibody is suitable for western blot at a dilution of 1:1,000-1:2,000.

Biochem/physiol Actions

Apoptosis or Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family proteases. These signals are generated by DNase in chromosomal DNA degradation. CIDE-A and CIDE-B induce DNA fragmentation and activate apoptosis in mammalian cells. The C-terminal region of CIDE-A is necessary and sufficient for killing. DFF45/ICAD is an inhibitor of caspase activated Dnase, DFF40/CAD and has also been shown to inhibit the apoptotic activities of CIDE-A and CIDE-B. The region of CIDE-A with homology to DFF45 located in the N-terminus was required for DFF45 to inhibit CIDE-A induced apoptosis. CIDE-A is expressed in many tissues including brain.

Features and Benefits

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Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.