C7599
Anti-Caspase 6 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
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About This Item
MDL number:
UNSPSC Code:
12352203
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 34 kDa
species reactivity
human
technique(s)
microarray: suitable
western blot: 1:1,000 using Jurkat human T-cell leukemia cell extract
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... CASP6(839)
General description
Caspase-6 (CASP6) is an enzyme encoded by the CASP6 gene in humans. It is a neuron degeneration-related protease and considered to be a potential drug-design target against neurodegenerative diseases.
Specificity
The antibody reacts specifically with procaspase 6 (Mch2).
Immunogen
synthetic peptide corresponding to the human N-terminal of procaspase 6α isoform (amino acids 27-44 with C-terminal added cysteine), conjugated to BSA. This sequence corresponds to the N-terminal of the human enzyme p18 subunit.
Application
Anti-Caspase 6 antibody produced in rabbit is suitable for microarray and western blotting at a dilution of 1:1,000 using Jurkat human T-cell leukemia cell extract.
Biochem/physiol Actions
Caspase-6 is strongly activated in Alzheimer disease brains and Huntington′s disease. It is important in most tissues during early development and is less involved in adult tissues. The low levels of Caspase-6 in fetal and adult brain indicate increased expression in Alzheimer Disease while the high levels of Caspase-6 in the gastrointestinal system indicate specific function of Caspase-6 in this tissues. It is a cysteinyl protease inducing axonal degeneration and is activated early in Alzheimer Disease (AD) brains. Casp6 is associated with the risk of developing AD in aged individuals.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk_germany
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Qin Cao et al.
Acta crystallographica. Section D, Biological crystallography, 70(Pt 1), 58-67 (2014-01-15)
Caspase 6 (CASP6) is a neuron degeneration-related protease and is widely considered to be a potential drug-design target against neurodegenerative diseases such as Huntington's disease and Alzheimer's disease. The N-terminal pro-peptide of CASP6, also referred to as the pro-domain, contains
Elih M Velázquez-Delgado et al.
The Journal of biological chemistry, 287(43), 36000-36011 (2012-08-15)
Zinc and caspase-6 have independently been implicated in several neurodegenerative disorders. Depletion of zinc intracellularly leads to apoptosis by an unknown mechanism. Zinc inhibits cysteine proteases, including the apoptotic caspases, leading to the hypothesis that zinc-mediated inhibition of caspase-6 might
Jasmine Ramcharitar et al.
Neurobiology of aging, 34(7), 1815-1824 (2013-02-14)
Caspase-6 (Casp6), a cysteinyl protease that induces axonal degeneration, is activated early in Alzheimer Disease (AD) brains. To determine whether Casp6 activation is responsible for early cognitive impairment, we investigated the abundance of Casp6 activity, paired helical filament-1 (PHF-1) phosphorylated
Nelly Godefroy et al.
PloS one, 8(11), e79313-e79313 (2013-11-23)
Caspase-6 is an effector caspase that has not been investigated thoroughly despite the fact that Caspase-6 is strongly activated in Alzheimer disease brains. To understand the full physiological impact of Caspase-6 in humans, we investigated Caspase-6 expression. We performed western
Ruth I Carlson et al.
Conservation physiology, 4(1), cow001-cow001 (2016-06-14)
A novel antibody-based protein microarray was developed that simultaneously determines expression of 31 stress-associated proteins in skin samples collected from free-ranging grizzly bears (Ursus arctos) in Alberta, Canada. The microarray determines proteins belonging to four broad functional categories associated with
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