C7159
Monoclonal Anti-Cytokeratin 4.62 antibody produced in mouse
clone K4.62, ascites fluid
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About This Item
MDL number:
UNSPSC Code:
12352203
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
K4.62, monoclonal
contains
15 mM sodium azide
species reactivity
human
technique(s)
indirect immunofluorescence: 1:20 using frozen human tissue sections
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... KRT19(3880)
Specificity
Reacts with cytokeratin polypeptide 19. The antibody labels the basal layer of non-keratinizing epithelium, metaplastic epithelium of the cervix, simple epithelium, transitional epithelium, squamous cell carcinomas and adenocarcinomas expressing cytokeratin 19.
Immunogen
cytoskeletal proteins from the cultured human breast carcinoma cell line MCF-7
Application
Monoclonal Anti-Cytokeratin 4.62 antibody produced in mouse is suitable for indirect immunofluorescence at a dilution of 1:20 using frozen human tissue sections.
Biochem/physiol Actions
Cytokeratins are proteins of keratin-containing intermediate filaments that provide mechanical support and other additional functions in epithelial cells. It is found in the intracytoplasmic cytoskeleton of epithelial tissue. Epithelial tissue expresses cytokeratin subunits in a specific and stable pattern. Cytokeratins along with vimentin are involved in cell proliferation, migration and differentiation of preodontoblasts and preameloblasts. The intermediate-sized filaments are abundant in human endothelial cells and are mostly of vimentin type.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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