Skip to Content
MilliporeSigma
All Photos(3)

Key Documents

View All Documentation

C6869

Sigma-Aldrich

Anti-CCRK (381-395) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Anti-CDCH, Anti-Cell cycle related kinase isoform 2 (Homo sapiens), Anti-p42

Sign Into View Organizational & Contract Pricing

Select a Size

200 μL
$532.00

$532.00

Check Cart for Availability
Request a Bulk Order
All Photos(3)

Select a Size

Change View
200 μL
$532.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

$532.00

Check Cart for Availability
Request a Bulk Order

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~36 kDa

species reactivity

human

technique(s)

western blot: 1:500-1:2,000

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CCRK(23552)

Immunogen

synthetic peptide corresponding to amino acids 381-395 of human CCRK.

Application

Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if. Anti-CCRK (381-395) antibody produced in rabbit is suitable for western blotting at a dilution of 1:500-1:2,000.

Biochem/physiol Actions

Cell cycle-related kinase (CCRK) is a protein kinase that is homologous to Cdk7. It is a candidate for oncogene in human glioblastoma tumorigenesis. CCRK is also involved in colorectal cancer carcinogenesis and G1/S cell cycle transition by regulating Cdk2, cyclin E and Rb. CCRK plays an important role in the control of cell proliferation via the regulation of cyclin D1 expression, and the overexpression of CCRK. It also acts as an independent molecular marker for shortened survival time of patients with ovarian carcinoma. CCRK along with its substrate ICK (intestinal cell kinase) inhibits ciliogenesis and glioblastoma cell proliferation. Depletion of CCRK leads to accumulation of ICK at ciliary tips, altered ciliary transport and leads to inhibition of cell cycle re-entry in NIH3T3 fibroblasts.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Not finding the right product?  

Try our Product Selector Tool.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
108K4825

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Ying Yang et al.
EMBO reports, 14(8), 741-747 (2013-06-08)
Loss of primary cilia is frequently observed in tumour cells, including glioblastoma cells, and proposed to benefit tumour growth, but a causal link has not been established. Here, we show that CCRK (cell cycle-related kinase) and its substrate ICK (intestinal
Guo-Qing Wu et al.
International journal of cancer, 125(11), 2631-2642 (2009-08-13)
Our previous study has suggested that the cell cycle-related kinase (CCRK) is a putative candidate oncogene in glioblastoma tumorigenesis. The potential oncogenic role of CCRK and its clinical/prognostic significance, however, in ovarian carcinoma are unclear. In this study, CCRK expression
Xiaomeng An et al.
European journal of cancer (Oxford, England : 1990), 46(9), 1752-1761 (2010-05-15)
Cell cycle-related kinase (CCRK) is a newly identified protein kinase homologous to Cdk7. We have previously shown that CCRK is a candidate oncogene in human glioblastoma. However, whether CCRK is a bona fide oncogene remains to be tested. The aim

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service