C6604
Anti-CINC-2β antibody produced in goat
affinity isolated antibody, lyophilized powder
Synonym(s):
Anti-Cytokine-Induced Neutrophil Chemoattractant 2β
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About This Item
UNSPSC Code:
51111800
NACRES:
NA.41
biological source
goat
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
rat
technique(s)
indirect ELISA: 0.5-1.0 μg/mL
western blot: 0.1-0.2 μg/mL
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
rat ... Cxcl3(171551)
General description
The neutrophil-attracting chemokines in rats are termed as cytokine-induced neutrophil chemoattractants (CINC). There are four CINC members, CINC-1, CINC-2α, CINC-2β and CINC-3. The CINC-2α and -2β members differ at the C-terminus. The members of CINC family signal through the CXCR2 receptor. The CINC members play a major role in recruitment of neutrophils in response to LPS into the rat lungs. Anti-CINC-2β antibody recognizes rat CINC-2β. It exhibits ~100% cross-reactivity with recombinant rat CINC-2α 50% cross-reactivity with mouse MIP-2, 35% cross-reactivity with mouse KC, 15% cross-reactivity with rat CINC-1, and 10% cross-reactivity with recombinant human IL-8, GROα, GROβ, and GROγ.
Specificity
The antibody recognizes recombinant rat CINC-2β. It exhibits ~100% cross-reactivity with recombinant rat CINC-2α, 50% cross-reactivity with mouse MIP-2, 35% cross-reactivity with mouse KC, 15% cross-reactivity with rat CINC-1, and 10% cross-reactivity with recombinant human IL-8, GROα, GROβ, and GROγ.
Immunogen
recombinant rat CINC-2β, expressed in E. coli.
Application
Anti-CINC-2β antibody may be used for immunoblotting at a working antibody concentration of 0.1-0.2 μg/ml may be used. For ELISA, a working antibody concentration of 0.5-1.0 μg/ml is recommended.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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F Shibata et al.
Cytokine, 12(9), 1368-1373 (2000-09-08)
Rat cytokine-induced neutrophil chemoattractant-1 (CINC-1), CINC-2 and CINC-3/macrophage inflammatory protein-2 (MIP-2), members of the CXC chemokine family, are potent chemotactic factors for neutrophils. In order to identify the receptor for CINCs, rat CXC chemokine receptor 2 (CXCR2) was cloned and
Kahoru Nishina et al.
American journal of respiratory cell and molecular biology, 33(5), 505-512 (2005-08-02)
Alveolar epithelial cells are among the first cells to encounter inhaled particles or organisms. These cells likely participate in the initiation and modulation of the inflammatory response by production of chemokines. However, there is little information on the extent or
H Nakagawa et al.
The Biochemical journal, 301 ( Pt 2), 545-550 (1994-07-15)
Four basic neutrophil chemotactic factors (chemokines) have been purified from conditioned medium of granulation tissue obtained from carrageenin-induced inflammation in the rat. On the basis of their N-terminal amino acid sequences, one of the chemokines was identical with rat GRO/cytokine-induced
F Shibata et al.
European journal of biochemistry, 231(2), 306-311 (1995-07-15)
Recently we found four cytokine-induced neutrophil chemoattractants, CINC-1, CINC-2 alpha, CINC-2 beta and CINC-3/macrophage inflammatory protein 2 (MIP-2), in conditioned medium of granulation tissue obtained from carrageenin-induced inflammation in rats [Nakagawa, H., Komorita, N., Shibata, F., Ikesue, A., Konishi, K.
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