C6235

Crosstide

≥97% (HPLC), lyophilized powder

• CAS Number: 171783-05-4
• MDL number: MFCD03787963
• UNSPSC Code: 12352200
• PubChem Substance ID: 329775117

Properties

• assay: ≥97% (HPLC)
• form: lyophilized powder
• mol wt: calculated mol wt 1164
• composition: Peptide content, ≥65%
• solubility: H₂O: soluble
• storage temp.: −20°C
• SMILES string: C[C@@H](O)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(O)=O
• InChI: 1S/C48H77N17O17/c1-24(38(74)59-28(14-15-35(70)71)39(75)56-21-36(72)73)57-41(77)30(19-26-9-4-3-5-10-26)61-42(78)31(22-66)62-43(79)32(23-67)63-45(81)37(25(2)68)64-40(76)27(11-6-16-54-47(50)51)60-44(80)33-13-8-18-65(33)46(82)29(58-34(69)20-49)12-7-17-55-48(52)53/h3-5,9-10,24-25,27-33,37,66-68H,6-8,11-23,49H2,1-2H3,(H,56,75)(H,57,77)(H,58,69)(H,59,74)(H,60,80)(H,61,78)(H,62,79)(H,63,81)(H,64,76)(H,70,71)(H,72,73)(H4,50,51,54)(H4,52,53,55)/t24-,25+,27-,28-,29-,30-,31-,32-,33-,37-/m0/s1
• InChI key: KJAXEBRGQOHHOY-VXRVIWLSSA-N
• Gene Information: human ... AKT1(207) ; mouse ... AKT1(11651) ; rat ... AKT1(24185)

Description

Amino Acid Sequence

Gly-Arg-Pro-Arg-Thr-Ser-Ser-Phe-Ala-Glu-Gly

Application

Crosstide has been used as a positive control in serine/threonine-protein kinase (akt) assay to test phosphorylation of serine 404 residue in lamin A [1] It has also been used as a substrate for Akt in in vitro kinase[2]

Biochem/physiol Actions

Crosstide is a serine/threonine-protein kinase (Akt) or protein kinase B β (PKBβ) substrate.[2]

Other Notes

Sequence from glycogen synthase kinase-3β

Safety Information

• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)