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C5743

Sigma-Aldrich

Cilastatin sodium salt

powder, ≥98% (HPLC)

Synonym(s):

Cilastatin sodium

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About This Item

Empirical Formula (Hill Notation):
C16H25N2NaO5S
CAS Number:
81129-83-1
Molecular Weight:
380.43
EC Number:
279-694-4
UNSPSC Code:
12352204
NACRES:
NA.77

product name

Cilastatin sodium salt, ≥98% (HPLC)

biological source

synthetic (organic)

assay

≥98% (HPLC)

form

powder

solubility

water: 10 mg/mL, clear, colorless to faintly yellow

storage temp.

2-8°C

InChI

1S/C16H26N2O5S.Na/c1-16(2)8-10(16)13(19)18-12(15(22)23)6-4-3-5-7-24-9-11(17)14(20)21;/h6,10-11H,3-5,7-9,17H2,1-2H3,(H,18,19)(H,20,21)(H,22,23);/q;+1/p-1/b12-6-;/t10-,11+;/m1./s1

InChI key

QXPBTTUOVWMPJN-QBNHLFMHSA-M

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General description

Cilastatin sodium salt is off-white to yellowish-white, hygroscopic, amorphous compound. It is derivatized from heptenoic acid. Its molecular mass is 380.43 g.

Biochem/physiol Actions

Inhibitor of the renal enzyme dehydropeptidase I and some bacterial zinc-containing β-lactamases. By these action, cilastatin suppresses both host and target metabolism of the broad-spectrum antibiotic imipenem, improving its efficacy.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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First-order derivative ultraviolet spectrophotometry of imipenem-cilastatin formulations.
Tabbouche OS and Soukkariyyeh I
Journal of Taibah University Medical Sciences, 9(3), 178-181 (2014)
Jinkyung Kim et al.
Proceedings of the National Academy of Sciences of the United States of America, 119(9) (2022-02-25)
Aminoglycosides (AGs) are commonly used antibiotics that cause deafness through the irreversible loss of cochlear sensory hair cells (HCs). How AGs enter the cochlea and then target HCs remains unresolved. Here, we performed time-lapse multicellular imaging of cochlea in live
Saurav Roy Choudhury et al.
Cell, 178(5), 1205-1221 (2019-08-24)
A hallmark feature of inflammation is the orchestrated recruitment of neutrophils from the bloodstream into inflamed tissue. Although selectins and integrins mediate recruitment in many tissues, they have a minimal role in the lungs and liver. Exploiting an unbiased in vivo

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