C5244
Anti-CAMK2B (30-44) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
Synonym(s):
Anti-CAM2, Anti-CAMK2, Anti-CAMKB, Anti-Calcium/calmodulin-dependent protein kinase IIB isoform 1 (Homo sapiens)
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All Photos(3)
About This Item
UNSPSC Code:
12352203
Recommended Products
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~72 kDa
species reactivity
human
technique(s)
western blot: 1:500-1:2,000
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CAMK2B(816)
General description
CAMKII/CAMK2 (Calcium/calmodulin-dependent protein kinase type II) is expressed from a family of four genes, α, β, γ, and δ. CAMK2B is highly expressed in barin tissue.
Immunogen
synthetic peptide corresponding to amino acids 30-44 of human CAMK2B.
Application
Anti-CAMK2B (30-44) antibody produced in rabbit for western blot at a dilution of 1:500-1:2,000.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.
Biochem/physiol Actions
Calcium/calmodulin-dependent protein kinase (CAMK) activates in the calcium-triggered CaMKK-CaMK1 signaling cascade. It regulates transcription activators, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth, upon calcium influx. CAMK controls axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. It is vital for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. It also plays a role in K+ and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. CAMKII/CAMK2 is the main CAMK in human skeletal muscle. CAMK2B promoter is methylated in breast cancer cell lines.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Adam J Rose et al.
The Journal of physiology, 574(Pt 3), 889-903 (2006-05-13)
Ca2+ signalling is proposed to play an important role in skeletal muscle function during exercise. Here, we examined the expression of multifunctional Ca2+-calmodulin-dependent protein kinases (CaMK) in human skeletal muscle and show that CaMKII and CaMKK, but not CaMKI or
Tara R Gaertner et al.
The Journal of biological chemistry, 279(13), 12484-12494 (2004-01-15)
Ca(2+)-calmodulin-dependent protein kinase II (CaM-kinase II) is a ubiquitous Ser/Thr-directed protein kinase that is expressed from a family of four genes (alpha, beta, gamma, and delta) in mammalian cells. We have documented the three-dimensional structures and the biophysical and enzymatic
T A McKinsey et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(26), 14400-14405 (2000-12-13)
Skeletal muscle differentiation is controlled by interactions between myocyte enhancer factor-2 (MEF2) and myogenic basic helix-loop-helix transcription factors. Association of MEF2 with histone deacetylases (HDAC) -4 and -5 results in repression of MEF2 target genes and inhibition of myogenesis. Calcium/calmodulin-dependent
CaMKK-CaMKI signaling pathways differentially control axon and dendrite elongation in cortical neurons.
April P Neal et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(8), 2807-2809 (2010-02-26)
Nataliya V Uboha et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 27(16), 4413-4423 (2007-04-20)
Calcium is a critical regulator of neuronal differentiation and neurite outgrowth during development, as well as synaptic plasticity in adulthood. Calcium- and calmodulin-dependent kinase I (CaMKI) can regulate neurite outgrowth; however, the signal transduction cascades that lead to its physiological
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