C4607
Anti-Cdk1 (p34cdc2) antibody produced in rabbit
whole antiserum
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About This Item
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
whole antiserum
antibody product type
primary antibodies
clone
polyclonal
mol wt
antigen 34 kDa
contains
0.05% sodium azide as preservative
species reactivity
human (predicted), rat (predicted), mouse
technique(s)
immunoprecipitation (IP): suitable
western blot (chemiluminescent): 1:500-1:2,000 using mouse 3T3 cell lysates
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... CDC2(983)
mouse ... Cdc2a(12534)
rat ... Cdc2(54237)
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General description
The gene Cyclin-dependent kinase 1 (CDK1) is mapped to human chromosome 10q21.1. The protein localizes in the cytoplasm and the nucleus. CDK1 is also popularly called as CDC2.
Immunogen
synthetic peptide corresponding to amino acids 263-287 of the C-terminus of mouse cdk1/cdc2.
Application
Anti-Cdk1 (p34cdc2) antibody produced in rabbit is suitable for immunoprecipitation and western blot (chemiluminescent) at a dilution of 1:500-1:2,000 using mouse 3T3 cell lysates.
Biochem/physiol Actions
Cyclin-dependent kinase 1 (CDK1) plays a vital role in the control of eukaryotic cell cycle by modulating the centrosome cycle and the onset of mitosis. It promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs. It is essential for development of early embryonic stage. The antibody may cross-react with other cdc2-like kinase. CDK1 is a component of M-phase promoting factor. CDK1 interacts with FAC (Fanconi anemia group C protein) and the binding is important for normal G2/M progression. Similarly, Cep63 binds and recruits Cdk1 to centrosomes, thereby regulating mitotic entry. CDK2 also foms a complex with cyclin E, cyclin A and cyclin D.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
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Sarah C Goetz et al.
Development (Cambridge, England), 133(13), 2575-2584 (2006-05-27)
Despite the critical importance of TBX5 in normal development and disease, relatively little is known about the mechanisms by which TBX5 functions in the embryonic heart. Our present studies demonstrate that TBX5 is necessary to control the length of the
Kazunori Tachibana et al.
Current biology : CB, 18(17), 1308-1313 (2008-08-15)
In sexual reproduction, the union of the male and female pronuclei occurs in fertilized eggs to mix genetic materials derived from both parents, thereby creating a new genome for the next generation [1-4]. The process leading to pronuclear union consists
Meng Qiao et al.
The Journal of biological chemistry, 281(11), 7118-7128 (2006-01-13)
RUNX2 is a member of the runt family of DNA-binding transcription factors. RUNX2 mediates endothelial cell migration and invasion during tumor angiogenesis and is expressed in metastatic breast and prostate tumors. Our published studies showed that RUNX2 DNA-binding activity is
Reiko Honda et al.
The EMBO journal, 24(3), 452-463 (2005-01-22)
Cyclin E, an activator of phospho-CDK2 (pCDK2), is important for cell cycle progression in metazoans and is frequently overexpressed in cancer cells. It is essential for entry to the cell cycle from G0 quiescent phase, for the assembly of prereplication
Masatoshi Hara et al.
Nature communications, 3, 1059-1059 (2012-09-13)
Maturation/M-phase-promoting factor is the universal inducer of M-phase in eukaryotic cells. It is currently accepted that M-phase-promoting factor is identical to the kinase cyclin B-Cdk1. Here we show that cyclin B-Cdk1 and M-phase-promoting factor are not in fact synonymous. Instead
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