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C4354

Sigma-Aldrich

Cytokine-Induced Neutrophil Chemoattractant-3 from rat

>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(s):

CINC-3, MIP-2

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About This Item

MDL number:
MFCD02687285
UNSPSC Code:
51111800

biological source

rat

recombinant

expressed in E. coli

assay

>97% (SDS-PAGE)

form

lyophilized powder

potency

1-3 mg per mL ED50

mol wt

calculated mol wt ~7.6 kDa

packaging

pkg of 25 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

P30348

storage temp.

−20°C

Gene Information

rat ... Cxcl2(114105)

Biochem/physiol Actions

CINC-3, a member of the α (CXC) subfamily of chemokines, is a potent chemotactic factor for rat neutrophils in vivo and in vitro. Rat and murine CINC-3 exhibits approximately 88% homology.

Physical form

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 1.25 mg bovine serum albumin.

Analysis Note

The biological activity is measured by its ability to induce myeloperoxidase release from cytochalasin B treated human neutrophils.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
090K1071

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S Huang et al.
The American journal of pathology, 141(4), 981-988 (1992-10-01)
This study sought to test the hypothesis that expression of mRNA for two cytokines, macrophage inflammatory protein-2 (MIP-2) and the KC gene product, is induced in rat lung cells during inflammatory responses in vitro and in vivo. Macrophage inflammatory protein-2
J M Schröder et al.
Journal of immunology (Baltimore, Md. : 1950), 139(10), 3474-3483 (1987-11-15)
A novel monocyte-derived neutrophil-activating peptide (MONAP) produced by lipopolysaccharide- and phorbol myristate acetate-stimulated human peripheral blood monocytes was purified by sequential ion exchange-high performance liquid chromatography (HPLC), size exclusion HPLC, and reversed phase HPLC. Biologic activities of the purified cytokine

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