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Key Documents

C4330

Sigma-Aldrich

Casein Kinase II-β fragment 198-215

≥95% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C90H153N27O26
Molecular Weight:
2029.34
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:

assay

≥95% (HPLC)

form

solid

UniProt accession no.

storage temp.

−20°C

SMILES string

CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCC(N)=O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

InChI

1S/C90H153N27O26/c1-12-47(8)70(86(139)107-57(89(142)143)26-20-36-100-90(98)99)115-87(140)71(50(11)120)116-78(131)54(25-17-19-35-92)106-85(138)69(46(6)7)114-84(137)64-27-21-37-117(64)88(141)63(43-119)113-76(129)53(24-16-18-34-91)103-81(134)60(40-51-22-14-13-15-23-51)110-82(135)61(41-68(97)124)111-83(136)62(42-118)112-73(126)49(10)101-72(125)48(9)102-75(128)55(29-32-66(95)122)104-80(133)59(39-45(4)5)109-77(130)56(30-33-67(96)123)105-79(132)58(38-44(2)3)108-74(127)52(93)28-31-65(94)121/h13-15,22-23,44-50,52-64,69-71,118-120H,12,16-21,24-43,91-93H2,1-11H3,(H2,94,121)(H2,95,122)(H2,96,123)(H2,97,124)(H,101,125)(H,102,128)(H,103,134)(H,104,133)(H,105,132)(H,106,138)(H,107,139)(H,108,127)(H,109,130)(H,110,135)(H,111,136)(H,112,126)(H,113,129)(H,114,137)(H,115,140)(H,116,131)(H,142,143)(H4,98,99,100)/t47-,48-,49-,50+,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,69-,70-,71-/m0/s1

InChI key

OMUTVGVKPXPHPX-TWWSAIDSSA-N

Gene Information

human ... CSNK2B(1460)

Amino Acid Sequence

Gln-Leu-Gln-Leu-Gln-Ala-Ala-Ser-Asn-Phe-Lys-Ser-Pro-Val-Lys-Thr-Ile-Arg

Biochem/physiol Actions

Cdc2 substrate and competitive inhibitor of apoptosis. Sequence contains CK II autophosphorylation site plus p34cdc2 consensus phosphorylation site Ser209.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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L Shi et al.
Science (New York, N.Y.), 263(5150), 1143-1145 (1994-02-25)
Activation of the serine-threonine kinase p34cdc2 at an inappropriate time during the cell cycle leads to cell death that resembles apoptosis. Premature activation of p34cdc2 was shown to be required for apoptosis induced by a lymphocyte granule protease. The kinase
D W Litchfield et al.
The Journal of biological chemistry, 266(30), 20380-20389 (1991-10-25)
To examine the phosphorylation of casein kinase II in cells, the enzyme was isolated by immunoprecipitation from metabolically labeled human epidermal carcinoma A431 cells using polyclonal antipeptide antibodies specific for either the alpha subunit or the beta subunit of the

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