C4116

Cyclopamine hydrate

≥98% (HPLC), solid, Hedgehog signaling pathway inhibitor

• Synonym(s): 11-deoxojervine hydrate
• Empirical Formula (Hill Notation): C₂₇H₄₁NO₂ · xH₂O
• CAS Number: 1217465-07-0
• Molecular Weight: 411.62 (anhydrous basis)
• UNSPSC Code: 12352116
• PubChem Substance ID: 24724439
• NACRES: NA.77

Properties

• product name: Cyclopamine hydrate, ≥98% (HPLC)
• assay: ≥98% (HPLC)
• form: solid
• color: white
• solubility: DMSO: soluble ≥5 mg/mL; H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: O.C[C@@H]1CN[C@H]2[C@@H](C)[C@@]3(CC[C@H]4[C@@H]5CC=C6C[C@@H](O)CC[C@]6(C)[C@H]5CC4=C3C)O[C@@H]2C1
• InChI: 1S/C27H41NO2.H2O/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2;/h5,15,17,19-21,23-25,28-29H,6-14H2,1-4H3;1H2/t15-,17+,19-,20-,21-,23-,24+,25-,26-,27-;/m0./s1
• InChI key: KDAGJRDPNXDDSB-HBYCUIHISA-N
• Gene Information: human ... EBP(10682)

Description

General description

Cyclopamine is a steroidal alkaloid, extracted from Veratrum californicum. It prevents tumor cell growth and invasiveness in vitro and in vivo.

Application

Cyclopamine hydrate has been used:

• as a sonic hedgehog (Shh) inhibitor in various experiments
• to explore the effects of stress stimulation on the proliferation and differentiation of fibrochondrocytes
• to study its influence on ocular vessel patterning

Biochem/physiol Actions

Cyclopamine is a Hedgehog signaling pathway inhibitor; inhibits the growth of medulloblastoma cells.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• ppe: Eyeshields, Gloves, type N95 (US)