C2854

Caspase 2 human

≥95% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous solution, >1000 units/mg protein

• Synonym(s): Ich-1, Nedd2
• MDL number: MFCD02686998
• UNSPSC Code: 12352200

Properties

• recombinant: expressed in E. coli
• assay: ≥95% (SDS-PAGE)
• form: buffered aqueous solution
• specific activity: >1000 units/mg protein
• mol wt: inactive proenzyme 56 kDa (active form consists of 17 kDa and 10 kDa subunits); ≥30 kDa
• UniProt accession no.: P42575
• storage temp.: −20°C
• Gene Information: human ... CASP2(835)

Description

Biochem/physiol Actions

Caspase 2 plays a major role in both positive and negative regulation of programmed cell death. It exists as two spliced variants, Ich-1L (long) and Ich-1S (short). Functionally, the two forms differ in that overexpression of the long form will induce apoptosis, while overexpression of the short form suppresses cell death.

Unit Definition

One unit will hydrolyze one nmol of N-Acetyl-Val-Asp-Val-Ala-Asp-AFC per min at pH 7.5 at 25 °C.

Physical form

Solution in 25 mM HEPES, pH 7.5, 0.15 M NaCl, 5 mM dithiothreitol, 10% sucrose, with 0.5 mg bovine serum albumin

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable