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C2538

Sigma-Aldrich

Carboplatin

Synonym(s):

cis-Diammine(1,1-cyclobutanedicarboxylato) platinum

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$237.00
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100 MG
$237.00
250 MG
$455.05

About This Item

Linear Formula:
[C4H6(CO2)2]Pt(NH3)2
CAS Number:
41575-94-4
Molecular Weight:
371.25
EC Number:
255-446-0
MDL number:
MFCD00070464
UNSPSC Code:
12352200
PubChem Substance ID:
24278303
NACRES:
NA.77

$237.00

Available to ship onMay 01, 2025Details

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form

powder

Quality Level

100

antibiotic activity spectrum

neoplastics

originator

Bristol-Myers Squibb

SMILES string

N.N.O=C1O[Pt]OC(=O)C12CCC2

InChI

1S/C6H8O4.2H3N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;+2/p-2

InChI key

OLESAACUTLOWQZ-UHFFFAOYSA-L

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General description

Carboplatin is used to treat testicular, ovarian and breast cancer.[1]

Application

Carboplatin has been used:
  • in chemotherapy-induced thrombocytopenia mouse model and treatment[2]
  • to induce cell death in a large subset of colorectal cancer cells[3]
  • in the evaluation of cell proliferation and chemosensitivity[4]
  • as a positive control for suppressed cell growth[5]

Biochem/physiol Actions

Carboplatin is a platinum-based antineoplastic drug that damages DNA by forming intrastrand cross-links with neighboring guanine residues. Tumors acquire resistance to these drugs through the loss of DNA-mismatch repair (MMR) activity and the resultant decrease in the induction of programmed cell death.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Muta. 1B - Repr. 1B - Resp. Sens. 1 - Skin Sens. 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
MKCW1333
MKCT7823
MKCR3593
MKCR8746
MKCK1243

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Mun Sem Liew et al.
BJU international, 112 Suppl 2, 74-82 (2013-10-30)
To review time-trends in the use of perioperative chemotherapy and its impact on oncological outcomes in patients with bladder urothelial cancer (UC) at a single tertiary institution. Using electronic and paper medical records, 89 patients were identified who underwent radical
Thomas' Hematopoietic Cell Transplantation, Volume 457 (2004)
Calpain system protein expression and activity in ovarian cancer
Zhang S, et al.
Journal of Cancer Research and Clinical Oncology, 1-17 (2018)
Shoji Nagao et al.
Gynecologic oncology, 131(3), 567-573 (2013-10-01)
The concept of "platinum sensitivity" has been widely applied in the management of recurrent ovarian cancer. This study aimed to evaluate the applicability of this concept to recurrent endometrial cancer. In this multicenter retrospective cohort study, the clinical data of
Joel Shapiro et al.
Annals of surgery, 258(5), 678-688 (2013-10-08)
To gain insight into the exact location of residual esophageal cancer in the esophageal wall and regional lymph nodes after neoadjuvant chemoradiotherapy (nCRT) and to determine the pattern of regression. Data from the recently published chemoradiotherapy for oesophageal cancer followed
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