C1897
Catechol-O-methyl Transferase from porcine liver
lyophilized powder, ≥150 units/mg protein
Synonym(s):
COMT, Pyrocatechol-O-methyl Transferase, S-Adenosyl-L-methionine:catechol O-methyltransferase
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About This Item
Recommended Products
form
lyophilized powder
specific activity
≥150 units/mg protein
purified by
chromatography
composition
Protein, 30-60% biuret
storage temp.
−20°C
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Biochem/physiol Actions
Major degradative enzyme for catecholamine neurotransmitters; methylates the o-hydroxyl group
Unit Definition
One unit will produce 1.0 nanomole of total O-methylated products from 3,4 dihydroxyacetophenone per hour at pH 7.6 at 37 °C.
Previous radioactive assay unit definition: One unit will catalyze the methylation of 1.0 nanomole of protocatechuic acid per hr at pH 7.9 at 37°C using S-adenosyl-L-[methyl-14C]methionine as the methyl donor. (~6 radioactive units equal one new unit).
Previous radioactive assay unit definition: One unit will catalyze the methylation of 1.0 nanomole of protocatechuic acid per hr at pH 7.9 at 37°C using S-adenosyl-L-[methyl-14C]methionine as the methyl donor. (~6 radioactive units equal one new unit).
Physical form
Lyophilized powder containing phosphate buffer and dithiothreitol
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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M C Wardle et al.
Genes, brain, and behavior, 12(1), 13-20 (2012-12-13)
In a widely cited study, Mattay et al. reported that amphetamine (0.25 mg/kg oral, or 17 mg for a 68 kg individual) impaired behavioral and brain indices of executive functioning, measured using the Wisconsin Card Sorting Task (WCST) and N-Back
Nidhi Jatana et al.
Journal of molecular graphics & modelling, 39, 145-164 (2013-01-03)
Catechol-O-methyltransferase (COMT) catalyzes the methylation of catecholamines, including neurotransmitters like dopamine, epinephrine and norepinephrine, leading to their degradation. COMT has been a subject of study for its implications in numerous neurological disorders like Parkinson's disease (PD), schizophrenia, and depression. The
Excessive daytime sleepiness and its risk factors in incident Parkinson's disease.
David P Breen et al.
Journal of neurology, neurosurgery, and psychiatry, 84(2), 233-234 (2012-11-28)
Luis Almeida et al.
Clinical pharmacokinetics, 52(2), 139-151 (2012-12-19)
Opicapone is a novel catechol-O-methyltransferase (COMT) inhibitor. The purpose of this study was to evaluate the tolerability, pharmacokinetics (including the effect of food) and pharmacodynamics (effect on COMT activity) following single oral doses of opicapone in young healthy male volunteers.
Ruth Landau et al.
Anesthesia and analgesia, 116(2), 386-391 (2013-01-11)
IV fentanyl is used as a labor analgesic; however, few studies have reported the effects of IV fentanyl for early labor analgesia. We evaluated the analgesic response to IV fentanyl according to the combined effect of the single-nucleotide polymorphisms rs1799971
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