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Key Documents

C176

Sigma-Aldrich

CGP-23996

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About This Item

MDL number:
MFCD00153780
UNSPSC Code:
12352202
NACRES:
NA.26

form

solid

Quality Level

100

mol wt

1474 (peptide free base)

color

white

solubility

0.1 M acetic acid: soluble

shipped in

dry ice

storage temp.

2-8°C

SMILES string

[nH]1c2c(c(c1)C[C@@H]3NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC3=O)CCCCN)[C@H](O)C)Cc6ccc(cc6)O)[C@H](O)C)CO)C(=O)O)CCCCN)CC(=O)N)Cc5ccccc5)Cc4ccccc4)cccc2

InChI

1S/C73H99N15O18/c1-41(90)61-71(103)85-55(36-45-28-30-47(92)31-29-45)69(101)88-62(42(2)91)72(104)86-58(40-89)70(102)80-52(73(105)106)26-10-5-11-27-60(94)78-50(24-14-16-32-74)63(95)84-57(38-59(76)93)68(100)82-53(34-43-18-6-3-7-19-43)65(97)81-54(35-44-20-8-4

InChI key

HTEPNQQGQXAYEW-MTBXKZQJSA-N

Application

Non-reducible analog of somatostatin suitable for iodination. The radio-iodinated molecule can be used in binding assays for somatostatin receptors.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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K Raynor et al.
Journal of neurochemistry, 59(4), 1241-1250 (1992-10-01)
Somatostatin (SRIF) is a neurotransmitter that produces its multiple effects in the CNS through interactions with membrane-bound receptors. Subtypes of SRIF receptors are found in the CNS that are distinguished by their sensitivities to the cyclic hexapeptide MK-678, such that
K Raynor et al.
The Journal of pharmacology and experimental therapeutics, 264(1), 110-116 (1993-01-01)
GH3 cells express receptors for the neuropeptide somatostatin (SRIF). In the present study, we have identified and characterized SRIF1 and SRIF2 receptors in GH3 cells using the radioligands [125I]MK 678 and [125I]CGP 23996. [125I]MK 678 binding to SRIF1 receptors was
J L Martin et al.
Neuroscience, 41(2-3), 581-593 (1991-01-01)
Somatostatin receptor subtypes were labeled with the somatostatin analogs [125I]CGP 23996 and [125I]MK 678 and the distribution of these receptors in rat brain was investigated using quantitative autoradiographic techniques. [125I]CGP 23996 and [125I]MK 678 specifically label different populations of somatostatin

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