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C1491

Sigma-Aldrich

Anti-Cyclic Nucleotide-Gated Cation Channel A3 (CNGA3) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Synonym(s):

Anti-CCNC1, Anti-CNG3

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About This Item

MDL number:
MFCD06798434
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

rat

technique(s)

western blot: 1:200 using rat brain membranes

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Cnga3(12790)
rat ... Cnga3(85257)

Specificity

Also recognizes the two published isoforms of CNGA3.

Immunogen

synthetic peptide corresponding to amino acids 594-611 of rat CNGA3. Mouse is 15/18 residues identical.

application

Anti-Cyclic Nucleotide-Gated Cation Channel A3 (CNGA3) antibody produced in rabbit is suitable for western blotting at a dilution of 1:200 using rat brain membranes.

Biochem/physiol Actions

Cyclic nucleotide-gated cation channel alpha-3 is a protein encoded by the CNGA3 gene in humans. It is also referred as CNG3, ACHM2, CCNC1, CCNCa, CNCG3 and CCNCalpha. A cyclic nucleotide-gated (CNG) channel serves as essential target for sensory transduction in retinal photoreceptors and olfactory receptor cells. CNGA3 subunits specify the arrangement of subunits containing L633P and other mutations which leads to interact between channel subunits or intersubunit. Its mutations are the most common cause of cone-rod dystrophies and achromatopsia.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, 1% BSA, and 0.05% sodium azide.

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Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
SLCN1437
SLCL6892
074K1624

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Gucan Dai et al.
American journal of physiology. Cell physiology, 305(2), C147-C159 (2013-04-05)
Cyclic nucleotide-gated (CNG) channels are critical for sensory transduction in retinal photoreceptors and olfactory receptor cells; their activity is modulated by phosphoinositides (PIPn) such as phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). An achromatopsia-associated mutation in cone photoreceptor CNGA3, L633P
Shiqiang Li et al.
JAMA ophthalmology, 132(9), 1076-1083 (2014-06-07)
Mutations in CNGA3 are the most common cause of achromatopsia and cone-rod dystrophies. To identify CNGA3 mutations in patients with cone dystrophies or Leber congenital amaurosis. Clinical data and genomic DNA in 267 Chinese probands from 138 families with cone
Haining Zhong et al.
Nature, 420(6912), 193-198 (2002-11-15)
Cyclic nucleotide-gated (CNG) channels are crucial for visual and olfactory transductions. These channels are tetramers and in their native forms are composed of A and B subunits, with a stoichiometry thought to be 2A:2B (refs 6, 7). Here we report

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