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C130

Sigma-Aldrich

Chloro-APB hydrobromide

solid

Synonym(s):

(±)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide, (±)-SKF-82958 hydrobromide, 6-Chloro-N-allyl-SKF-38393 hydrobromide

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5 MG
$183.00
25 MG
$628.00

$183.00

Available to ship onApril 29, 2025Details

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5 MG
$183.00
25 MG
$628.00

About This Item

Empirical Formula (Hill Notation):
C19H20ClNO2 · HBr
CAS Number:
80751-65-1
Molecular Weight:
410.73
MDL number:
MFCD00069235
UNSPSC Code:
12352200
PubChem Substance ID:
24277890
NACRES:
NA.77

$183.00

Available to ship onApril 29, 2025Details

Request a Bulk Order

form

solid

Quality Level

100

color

tan

solubility

H2O: 3.7 mg/mL
aqueous base: unstable
ethanol: soluble

storage temp.

2-8°C

SMILES string

Br.Oc1cc2C(CN(CCc2c(Cl)c1O)CC=C)c3ccccc3

InChI

1S/C19H20ClNO2.BrH/c1-2-9-21-10-8-14-15(11-17(22)19(23)18(14)20)16(12-21)13-6-4-3-5-7-13;/h2-7,11,16,22-23H,1,8-10,12H2;1H

InChI key

WLXGFAVTAAQOFH-UHFFFAOYSA-N

Gene Information

human ... DRD1(1812)

Application

Chloro-APB hydrobromide has been used to pharmacologically stimulate D1 dopamine receptors and study its influence on locomotor response in fat mass and obesity-associated protein (FTO) deficient dopamine D1 receptor-expressing medium spiny neurons (D1 MSNs) of mice.[1]

Biochem/physiol Actions

Chloro-APB hydrobromide, also known as SKF 82958, is a D1 dopamine receptor agonist.[1] D1 receptor agonists prevent and reverse fentanyl-induced respiratory depression, without impairing opioid analgesia, in cats.[2]

Caution

Light sensitive

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000270648
075M4609V
128H4606
087H4660

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K D Carr et al.
Neuroscience, 165(4), 1074-1086 (2009-11-26)
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Jennifer L Cornish et al.
Journal of psychopharmacology (Oxford, England), 22(1), 100-110 (2008-01-12)
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A M Murray et al.
European journal of pharmacology, 160(3), 377-384 (1989-02-07)
A range of 3- and 6-substituted 1-phenyl-1H-3-benzazepine analogues of SK&F 38393 with D-1 agonist activity were compared for their behavioural effects in the intact adult rat and for their relative affinities for D-1 and D-2 dopamine receptors in vitro. All
Chinwe A Nwaneshiudu et al.
Neuropharmacology, 57(3), 295-301 (2009-06-09)
Acute activation or blockade of neurokinin-3 (NK-3) receptors has been shown to alter dopamine-mediated function and behaviors, however long-term effects of NK-3 receptor blockade remain largely unknown. The present study investigated whether acute and repeated administration of the NK-3 receptor
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