C0922
Tyr-Corticotropin Releasing Factor Ovine
≥97% (HPLC), Synthetic
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About This Item
Empirical Formula (Hill Notation):
C214H348N60O65S
CAS Number:
Molecular Weight:
4833.48
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.26
assay
≥97% (HPLC)
form
powder
storage temp.
−20°C
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Amino Acid Sequence
Tyr-Ser-Gln-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Thr-Lys-Ala-Asp-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Leu-Asp-Ile-Ala-NH2
Application
CRF analog used to prepare iodinated CRF for receptor studies and immunoassay
Other Notes
Lyophilized from 0.1% TFA in H2O
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Binding of [125I]Tyr-corticotropin-releasing factor to rabbit aorta is reduced by removal of the endothelium.
M R Dashwood et al.
European journal of pharmacology, 135(1), 111-112 (1987-03-03)
I Q Assil et al.
Peptides, 22(7), 1055-1061 (2001-07-11)
The methionine residues in Tyr-corticotropin-releasing factor (CRF) and Tyr-sauvagine radioligands are subject to oxidation, which renders them biologically inactive. Therefore [Tyr(0,) Gln(1,) Leu(17)]sauvagine (YQLS), in which the methionine was replaced with leucine was synthesized and labeled with (125)Iodine using chloramine-T.
A V Turnbull et al.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 215(1), 1-10 (1997-05-01)
Corticotropin-releasing factor (CRF) is a 41-amino acid neuropeptide, which is recognized as a critical mediator of complimentary, stress-related endocrine, autonomic, and behavioral responses in mammalian species. CRF belongs to a family of structurally related peptides including frogskin sauvagine and fish
K Eckart et al.
Current medicinal chemistry, 6(11), 1035-1053 (1999-10-16)
Corticotropin-releasing factor (CRF), urocortin, sauvagine and urotensin I form the CRF family. These peptides bind with different affinities to two subtypes of CRF receptor (CRFR), CRFR1 and CRFR2. The latter exists as two splice variants, the neuronal CRFR2a and the
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