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C0845

Sigma-Aldrich

6Ckine from mouse

≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(s):

Exodus-2, SLC

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About This Item

CAS Number:
196414-88-7
MDL number:
MFCD01632892
UNSPSC Code:
51111800

biological source

mouse

recombinant

expressed in E. coli

assay

≥98% (HPLC)
≥98% (SDS-PAGE)

form

lyophilized powder

mol wt

16-17 kDa by SDS-PAGE

packaging

pkg of 25 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

P84444
P86792
P86792
P86792

storage temp.

−20°C

Gene Information

mouse ... Ccl21a(18829) , Ccl21b(20298)

Biochem/physiol Actions

The expression of mouse 6Ckine has been detected at high levels in the spleen and lung. Recombinant mouse 6Ckine chemotattracts in vitro thymocytes and activated T-cells.

Physical form

Lyophilized with no additives.

Analysis Note

The biological activity is measured by its ability to chemoattract total murine T cell population.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
011M1770
123K0988
113K1025

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Long Chen et al.
Molecular cancer, 12(1), 153-153 (2013-12-07)
Secondary lymphoid tissue chemokine (SLC) is a key CC chemokine for chemotaxis of immune cells and has been an attractive candidate for anti-tumor treatments. However, among the immune cells recruited by SLC to tumors, the CD25+ Foxp3+ regulatory T cells
Alexei Y Savinov et al.
The Journal of experimental medicine, 197(5), 643-656 (2003-03-05)
Activated insulin-specific CD8(+) T cells (IS-CD8(+) cells) home to the pancreas, destroy beta cells, and cause rapid diabetes upon transfer into diabetes-prone NOD mice. Surprisingly, they also cause diabetes in mouse strains that are free of preexistent inflammation. Thus, we
W Weninger et al.
The Journal of experimental medicine, 194(7), 953-966 (2001-10-03)
It has been proposed that two different antigen-experienced T cell subsets may be distinguishable by their preferential ability to home to lymphoid organs (central memory cells) or nonlymphoid tissues (effector memory/effector cells). We have shown recently that murine antigen-primed CD8(+)
Rilun Li et al.
Molecular biology reports, 40(10), 5615-5623 (2013-10-01)
To explore the anti-tumor effect and immune mechanism mediated by a new recombinant adeno-associated virus (rAAV) encoding secondary lymphoid tissue chemokine (SLC) mature peptide gene. AAV Helper-Free system was used for rAAV-SLC package. The anti-tumor effect of SLC was detected
Sherven Sharma et al.
Molecular cancer, 2, 22-22 (2003-05-13)
SLC/CCL21, normally expressed in high endothelial venules and in T cell zones of spleen and lymph nodes, strongly attracts T cells and dendritic cells (DC). We have previously shown that SLC/CCL21-mediated anti-tumor responses are accompanied by significant induction of IFNgamma

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