C0746
Monoclonal Anti-Cytochrome P450 2C6 (CYP2C6) antibody produced in mouse
~1.0 mg/mL, clone K1, purified immunoglobulin, buffered aqueous solution
Synonym(s):
Anti-CYPIIC6, Anti-Cyp2c6, Anti-Cytochrome P450, Anti-P450 PB1, Anti-PTF2, Anti-Subfamily IIC6
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About This Item
UNSPSC Code:
12352203
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
K1, monoclonal
form
buffered aqueous solution
mol wt
antigen ~49 kDa
species reactivity
rat, human
concentration
~1.0 mg/mL
technique(s)
indirect ELISA: suitable
western blot: 0.25-0.5 μg/mL using rat liver total extract.
isotype
IgG1
shipped in
dry ice
storage temp.
−20°C
Gene Information
rat ... Cyp2c6v1(293989)
General description
Cytochrome P450 enzymes are a heme containing mono oxygenase superfamily that in humans are involved in oxidative metabolism of xenobiotics. This metabolism is the initial step in the biotransformation and elimination of a wide variety of drugs and environmental pollutants from the body.
Specificity
The antibody reacts with rat CYP 2C6 and human CYP 2C9, as well as other CYP 2C human proteins. It also reacts with phenobarbital-induced CYP 2C proteins in mice. It should be noted that the antibody does not react with human, rat, and mouse CYP 2C8.
Immunogen
rat liver cytochrome P450 2C6.
Application
Monoclonal Anti-Cytochrome P450 2C6 (CYP2C6) antibody produced in mouse is suitable for indirect ELISA and for western blotting at a concentration of 0.25-0.5mg/mL using rat liver total extract.
Biochem/physiol Actions
Cytochrome P450 enzymes plays an important role in cancer therapy. The rat CYP 2C6 is regarded as a counterpart of human CYP 2C9. CYP2C6 gene is transcriptionally activated in livers of postpubertal rats. In humans, this subfamily is responsible for the metabolism of a variety of therapeutic drugs. Both isoforms specifically catalyze the 4-hydroxylation of diclofenac, phenytoin and warfarin. They can produce 21-hydroxyprogesterone which are inhibited by sulfaphenazole and are induced by phenobarbital.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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J A Goldstein
British journal of clinical pharmacology, 52(4), 349-355 (2001-10-27)
The human CYP2Cs are an important subfamily of P450 enzymes that metabolize approximately 20% of clinically used drugs. There are four members of the subfamily, CYP2C8, CYP2C9, CYP2C19, and CYP2C18. Of these CYP2C8, CYP2C9, and CYP2C19 are of clinical importance.
Rostislav Vecera et al.
Neuro endocrinology letters, 33 Suppl 3, 48-52 (2013-01-29)
The aim of this study was to investigate whether rosuvastatin affects expression and activity of rat CYP2C6. This cytochrome P450 is considered to be a counterpart of human CYP2C9, which metabolizes many drugs, including diclofenac, ibuprofen or warfarin. Male hereditary
M Yano et al.
Molecular and cellular biology, 12(6), 2847-2854 (1992-06-01)
The CYP2C6 gene becomes maximally transcriptionally activated in livers of postpubertal rats. We examined the role of upstream DNA and liver-specific transcription factors in regulation of this promoter by use of transient transfection of heterologous chloramphenicol acetyltransferase gene constructs and
W A Daniel et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 16(8), 580-587 (2006-03-01)
The aim of the present study was to investigate the influence of tricyclic antidepressants (TADs: imipramine, amitriptyline, clomipramine, desipramine), selective serotonin reuptake inhibitors (SSRIs: fluoxetine, sertraline) and novel antidepressant drugs (mirtazapine, nefazodone) on the activity of CYP2C6 measured as a
Hollie I Swanson
Chemico-biological interactions, 149(2-3), 69-79 (2004-10-27)
The goal of this review is to stress the importance of the cytochrome P450 (CYP) superfamily that is expressed in human skin in the hope that it may stimulate further study in an intriguing topic that currently suffers from a
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