BM0030

BMS-248360

≥98% (HPLC)

• Synonym(s): 4′-[(2-Butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-N-(3,4-dimethyl-5-isoxazolyl)-2′-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl][1,1′-biphenyl]-2-sulfonamide
• Empirical Formula (Hill Notation): C₃₆H₄₅N₅O₅S
• CAS Number: 254737-87-6
• Molecular Weight: 659.84
• MDL number: MFCD09027363
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: room temp
• SMILES string: CCCCC(N1CC2=CC=C(C3=CC=CC=C3S(=O)(NC4=C(C)C(C)=NO4)=O)C(CN5CCC(C)(C)C5=O)=C2)=NC6(CCCC6)C1=O
• InChI: 1S/C36H45N5O5S/c1-6-7-14-31-37-36(17-10-11-18-36)34(43)41(31)22-26-15-16-28(27(21-26)23-40-20-19-35(4,5)33(40)42)29-12-8-9-13-30(29)47(44,45)39-32-24(2)25(3)38-46-32/h8-9,12-13,15-16,21,39H,6-7,10-11,14,17-20,22-23H2,1-5H3
• InChI key: NBDFXMDYBLSGLX-UHFFFAOYSA-N

Description

Biochem/physiol Actions

BMS-248360 is an orally active dual antagonist of angiotensin II subtype 1 (AT1) and endothelin subtype A (ETA) receptors.

BMS-248360 is an orally active dual antagonist of angiotensin II subtype 1 (AT1) and endothelin subtype A (ETA) receptors. BMS-248360 exhibited a broader spectrum of antihypertensive activity when compared to individual AT1 or ETA receptor antagonists.

Features and Benefits

BMS-248360 is available through a partnership with Bristol-Myers Squibb (BMS). To learn more and view other BMS compounds, visit sigma.com/BMS.

Legal Information

Sold for research purposes only under agreement from BMS.

Safety Information

• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable