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Key Documents

BM0013

Sigma-Aldrich

BMS-281384 bis-HCl

≥98% (HPLC)

Synonym(s):

4-[[(3-Chloro-4-methoxyphenyl)methyl]amino]-1-ethyl-N-(4-pyridinylmethyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide bis-HCl

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About This Item

Empirical Formula (Hill Notation):
C23H23ClN6O2 · 2HCl
CAS Number:
Molecular Weight:
523.84
UNSPSC Code:
12352200
PubChem Substance ID:

Quality Level

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

room temp

SMILES string

[H]Cl.[H]Cl.ClC1=C(OC)C=CC(CNC2=C(C=NN3CC)C3=NC=C2C(NCC4=CC=NC=C4)=O)=C1

Biochem/physiol Actions

BMS-281384 is a selective and potent phosphodiesterase 5 (PDE 5) inhibitor.
BMS-281384 is a selective and potent phosphodiesterase 5 (PDE 5) inhibitor. BMS-281384 was found to have an IC50 value of 0.8 nM for PDE5 and 47 to 9200-fold selective over other PDEs 1-6.

Features and Benefits

BMS-281384 is available through a partnership with Bristol-Myers Squibb (BMS). To learn more and view other BMS compounds, visit sigma.com/BMS.

Legal Information

Sold for research purposes only under agreement from BMS.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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